Detailed information NTG0998854

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: ABD411_RS04980
• Genome accession: NZ_CP155734
• Coordinates: 947232..948068 (+)
• Length: 278 a.a.
• NCBI ID: WP_023611998.1
• Uniprot ID: A0A5S4TFX7
• Organism: Streptococcus pyogenes strain 8373/17
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 942232..953068

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABD411_RS04950 (ABD411_04925)	-	942786..943154 (+)	369	WP_010922310.1	hypothetical protein	-
ABD411_RS04955 (ABD411_04930)	-	943204..944115 (-)	912	WP_023612012.1	diacylglycerol kinase family protein	-
ABD411_RS04960 (ABD411_04935)	-	944232..944882 (-)	651	WP_002984629.1	hemolysin III family protein	-
ABD411_RS04965 (ABD411_04940)	-	944879..945319 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
ABD411_RS04970 (ABD411_04945)	ylqF	945538..946386 (+)	849	WP_023611994.1	ribosome biogenesis GTPase YlqF	-
ABD411_RS04975 (ABD411_04950)	-	946376..947167 (+)	792	WP_023612045.1	ribonuclease HII	-
ABD411_RS04980 (ABD411_04955)	dprA	947232..948068 (+)	837	WP_023611998.1	DNA-processing protein DprA	Machinery gene
ABD411_RS04985 (ABD411_04960)	topA	948176..950305 (+)	2130	WP_050336211.1	type I DNA topoisomerase	-
ABD411_RS04990 (ABD411_04965)	-	950380..951264 (-)	885	Protein_936	LysR family transcriptional regulator	-
ABD411_RS04995 (ABD411_04970)	-	951277..951843 (+)	567	Protein_937	PTS sugar transporter subunit IIC	-
ABD411_RS05000 (ABD411_04975)	-	951858..952850 (+)	993	WP_023612447.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 30958.92 Da
• Isoelectric Point: 8.8230

>NTDB_id=998854 ABD411_RS04980 WP_023611998.1 947232..948068(+) (dprA) [Streptococcus pyogenes strain 8373/17]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPGEEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGAACVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=998854 ABD411_RS04980 WP_023611998.1 947232..948068(+) (dprA) [Streptococcus pyogenes strain 8373/17]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCTGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACTGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAATCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACTATC
GCTATTATTGGAACAGGATTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAGGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAGCATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A5S4TFX7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.791	100	0.608
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis SK321	60.791	100	0.608
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.432	100	0.604
dprA	Lactococcus lactis subsp. cremoris KW2	57.554	100	0.576
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367