Detailed information NTG0997598

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ABC806_RS08565
• Genome accession: NZ_CP155539
• Coordinates: 1650059..1650796 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae TIGR4
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1645059..1655796

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC806_RS08540 (ABC806_08530)	comA/nlmT	1645434..1646414 (+)	981	WP_306424562.1	ABC transporter transmembrane domain-containing protein	Regulator
ABC806_RS08545 (ABC806_08535)	comA/nlmT	1646442..1647077 (+)	636	WP_307772057.1	ATP-binding cassette domain-containing protein	Regulator
ABC806_RS08550 (ABC806_08540)	-	1647088..1648449 (+)	1362	WP_001069075.1	bacteriocin secretion accessory protein	-
ABC806_RS08555 (ABC806_08545)	blpC	1648506..1648634 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
ABC806_RS08560 (ABC806_08550)	-	1648705..1650045 (-)	1341	WP_001017646.1	sensor histidine kinase	-
ABC806_RS08565 (ABC806_08555)	comE/blpR	1650059..1650796 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
ABC806_RS08570 (ABC806_08560)	-	1650801..1651139 (-)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
ABC806_RS08575 (ABC806_08565)	-	1651415..1651744 (+)	330	WP_000132572.1	hypothetical protein	-
ABC806_RS08580 (ABC806_08570)	-	1651912..1652961 (-)	1050	WP_000653779.1	ABC transporter permease	-
ABC806_RS08585 (ABC806_08575)	pptA	1652958..1653689 (-)	732	WP_000889924.1	ABC transporter ATP-binding protein	Regulator
ABC806_RS08590 (ABC806_08580)	-	1653757..1654167 (+)	411	WP_001278301.1	HIT family protein	-
ABC806_RS08595 (ABC806_08585)	-	1654177..1654464 (+)	288	WP_000777760.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=997598 ABC806_RS08565 WP_001219120.1 1650059..1650796(-) (comE/blpR) [Streptococcus pneumoniae TIGR4]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=997598 ABC806_RS08565 WP_001219120.1 1650059..1650796(-) (comE/blpR) [Streptococcus pneumoniae TIGR4]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363