Detailed information NTG0997580

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ABC806_RS05220
• Genome accession: NZ_CP155539
• Coordinates: 996192..996896 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae TIGR4
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 991192..1001896

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC806_RS05195 (ABC806_05190)	coaC	991481..992032 (-)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-
ABC806_RS05200 (ABC806_05195)	coaB	992044..992733 (-)	690	WP_000699501.1	phosphopantothenate--cysteine ligase	-
ABC806_RS05205 (ABC806_05200)	-	992963..994633 (+)	1671	WP_000845295.1	formate--tetrahydrofolate ligase	-
ABC806_RS05210 (ABC806_05205)	-	994739..994864 (-)	126	WP_001818232.1	hypothetical protein	-
ABC806_RS05215 (ABC806_05210)	mutY	994961..996136 (+)	1176	WP_000886146.1	A/G-specific adenine glycosylase	-
ABC806_RS05220 (ABC806_05215)	micA	996192..996896 (+)	705	WP_000722076.1	response regulator YycF	Regulator
ABC806_RS05225 (ABC806_05220)	micB	996889..998238 (+)	1350	WP_000886219.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ABC806_RS05230 (ABC806_05225)	vicX	998240..999049 (+)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
ABC806_RS05235 (ABC806_05230)	relB	999140..999382 (+)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
ABC806_RS05240 (ABC806_05235)	-	999384..999638 (+)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ABC806_RS05245 (ABC806_05240)	-	999713..1001584 (+)	1872	WP_000150986.1	Eco57I restriction-modification methylase domain-containing protein	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=997580 ABC806_RS05220 WP_000722076.1 996192..996896(+) (micA) [Streptococcus pneumoniae TIGR4]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=997580 ABC806_RS05220 WP_000722076.1 996192..996896(+) (micA) [Streptococcus pneumoniae TIGR4]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACAAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38