Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   ABC806_RS05225 Genome accession   NZ_CP155539
Coordinates   996889..998238 (+) Length   449 a.a.
NCBI ID   WP_000886219.1    Uniprot ID   -
Organism   Streptococcus pneumoniae TIGR4     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 991889..1003238
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC806_RS05200 (ABC806_05195) coaB 992044..992733 (-) 690 WP_000699501.1 phosphopantothenate--cysteine ligase -
  ABC806_RS05205 (ABC806_05200) - 992963..994633 (+) 1671 WP_000845295.1 formate--tetrahydrofolate ligase -
  ABC806_RS05210 (ABC806_05205) - 994739..994864 (-) 126 WP_001818232.1 hypothetical protein -
  ABC806_RS05215 (ABC806_05210) mutY 994961..996136 (+) 1176 WP_000886146.1 A/G-specific adenine glycosylase -
  ABC806_RS05220 (ABC806_05215) micA 996192..996896 (+) 705 WP_000722076.1 response regulator YycF Regulator
  ABC806_RS05225 (ABC806_05220) micB 996889..998238 (+) 1350 WP_000886219.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ABC806_RS05230 (ABC806_05225) vicX 998240..999049 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ABC806_RS05235 (ABC806_05230) relB 999140..999382 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ABC806_RS05240 (ABC806_05235) - 999384..999638 (+) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ABC806_RS05245 (ABC806_05240) - 999713..1001584 (+) 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
  ABC806_RS05250 - 1001749..1002597 (+) 849 Protein_989 DEAD/DEAH box helicase family protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51698.39 Da        Isoelectric Point: 4.9706

>NTDB_id=997581 ABC806_RS05225 WP_000886219.1 996889..998238(+) (micB) [Streptococcus pneumoniae TIGR4]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQVNQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=997581 ABC806_RS05225 WP_000886219.1 996889..998238(+) (micB) [Streptococcus pneumoniae TIGR4]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAGTCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACTAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTACTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

PAS fold (PAS)

(98-198)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.555

100

0.996
  vicK Streptococcus mutans UA159

69.9

89.532

0.626

Multiple sequence alignment