Detailed information NTG0997330

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ABC811_RS07715
• Genome accession: NZ_CP155535
• Coordinates: 1490002..1490589 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PJ755/1
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1485002..1495589

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC811_RS07670 (ABC811_07665)	blpM	1485218..1485472 (-)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
ABC811_RS07680 (ABC811_07675)	-	1486683..1487497 (+)	815	Protein_1519	IS5-like element IS1515 family transposase	-
ABC811_RS07685 (ABC811_07680)	-	1487511..1487906 (-)	396	WP_000846569.1	hypothetical protein	-
ABC811_RS07690 (ABC811_07685)	-	1487903..1488067 (-)	165	WP_000727118.1	hypothetical protein	-
ABC811_RS07695 (ABC811_07690)	-	1488366..1488485 (-)	120	WP_001844187.1	PncF family bacteriocin immunity protein	-
ABC811_RS07700 (ABC811_07695)	blpU	1488488..1488718 (-)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
ABC811_RS07705 (ABC811_07700)	blpJ	1488787..1489056 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
ABC811_RS07710 (ABC811_07705)	blpI	1489523..1489720 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
ABC811_RS07715 (ABC811_07710)	comA/nlmT	1490002..1490589 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
ABC811_RS07720 (ABC811_07715)	comA/nlmT	1490681..1492171 (+)	1491	WP_001818755.1	peptide cleavage/export ABC transporter	Regulator
ABC811_RS07725 (ABC811_07720)	-	1492182..1493543 (+)	1362	WP_001069071.1	bacteriocin secretion accessory protein	-
ABC811_RS07730 (ABC811_07725)	blpC	1493600..1493755 (+)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
ABC811_RS07735 (ABC811_07730)	-	1493799..1495139 (-)	1341	WP_001099892.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=997330 ABC811_RS07715 WP_000205166.1 1490002..1490589(+) (comA/nlmT) [Streptococcus pneumoniae strain PJ755/1]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=997330 ABC811_RS07715 WP_000205166.1 1490002..1490589(+) (comA/nlmT) [Streptococcus pneumoniae strain PJ755/1]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497