Detailed information NTG0997170

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: ABC814_RS06510
• Genome accession: NZ_CP155533
• Coordinates: 1270226..1271074 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705310.1
• Uniprot ID: C1C7P4
• Organism: Streptococcus pneumoniae strain Spn1439-106
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1265226..1276074

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC814_RS06490 (ABC814_06485)	-	1265580..1265939 (-)	360	WP_001237219.1	YbaN family protein	-
ABC814_RS06495 (ABC814_06490)	topA	1266045..1268132 (-)	2088	WP_000179641.1	type I DNA topoisomerase	-
ABC814_RS06500 (ABC814_06495)	-	1268299..1269342 (-)	1044	WP_015898771.1	DUF389 domain-containing protein	-
ABC814_RS06505 (ABC814_06500)	-	1269920..1270042 (+)	123	WP_001814242.1	hypothetical protein	-
ABC814_RS06510 (ABC814_06505)	dprA/cilB/dalA	1270226..1271074 (-)	849	WP_000705310.1	DNA-processing protein DprA	Machinery gene
ABC814_RS06515 (ABC814_06510)	-	1271170..1271859 (-)	690	WP_000643970.1	sugar phosphate nucleotidyltransferase	-
ABC814_RS06520 (ABC814_06515)	-	1271871..1272749 (-)	879	WP_000837609.1	DMT family transporter	-
ABC814_RS06525 (ABC814_06520)	licA	1272739..1273608 (-)	870	WP_000411199.1	choline kinase LicA	-
ABC814_RS06530 (ABC814_06525)	-	1273625..1274647 (-)	1023	WP_000609894.1	ribitol-5-phosphate dehydrogenase	-
ABC814_RS06535 (ABC814_06530)	-	1274652..1275359 (-)	708	WP_000638502.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31080.76 Da
• Isoelectric Point: 5.4047

>NTDB_id=997170 ABC814_RS06510 WP_000705310.1 1270226..1271074(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain Spn1439-106]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGMAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=997170 ABC814_RS06510 WP_000705310.1 1270226..1271074(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain Spn1439-106]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTATTGGGTGATATTGCAGATATCTCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTATGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: C1C7P4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.645	100	0.996
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.227	100	0.982
dprA/cilB/dalA	Streptococcus mitis SK321	97.518	100	0.975
dprA	Streptococcus mutans UA159	62.857	99.291	0.624
dprA	Lactococcus lactis subsp. cremoris KW2	55.357	99.291	0.55
dprA	Staphylococcus aureus N315	37.456	100	0.376