Detailed information NTG0994619

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: AAFU62_RS00330
• Genome accession: NZ_CP154891
• Coordinates: 53234..54145 (+)
• Length: 303 a.a.
• NCBI ID: WP_136268451.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 318231
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48234..59145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAFU62_RS00310 (AAFU62_00310)	purE	48519..49010 (+)	492	WP_136098267.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
AAFU62_RS00315 (AAFU62_00315)	purK	48997..50070 (+)	1074	WP_194118154.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
AAFU62_RS00320 (AAFU62_00320)	-	50097..51794 (+)	1698	WP_136268453.1	AIPR family protein	-
AAFU62_RS00325 (AAFU62_00325)	purB	51812..53104 (+)	1293	WP_129321630.1	adenylosuccinate lyase	-
AAFU62_RS00330 (AAFU62_00330)	comR	53234..54145 (+)	912	WP_136268451.1	XRE family transcriptional regulator	Regulator
AAFU62_RS00335 (AAFU62_00335)	comS	54236..54334 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
AAFU62_RS00340 (AAFU62_00340)	ruvB	54365..55363 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
AAFU62_RS00345 (AAFU62_00345)	-	55501..55938 (+)	438	WP_111689441.1	low molecular weight protein-tyrosine-phosphatase	-
AAFU62_RS00350 (AAFU62_00350)	-	55961..56362 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
AAFU62_RS00355 (AAFU62_00355)	-	56359..58134 (+)	1776	WP_053308140.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35873.47 Da
• Isoelectric Point: 4.8488

>NTDB_id=994619 AAFU62_RS00330 WP_136268451.1 53234..54145(+) (comR) [Streptococcus pyogenes strain 318231]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELN
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=994619 AAFU62_RS00330 WP_136268451.1 53234..54145(+) (comR) [Streptococcus pyogenes strain 318231]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAC
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.01	100	0.99
comR	Streptococcus pyogenes MGAS8232	58.14	99.34	0.578
comR	Streptococcus mutans UA159	46.823	98.68	0.462
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.102	97.36	0.449
comR	Streptococcus suis P1/7	37.037	98.02	0.363
comR	Streptococcus suis 05ZYH33	37.037	98.02	0.363