Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SP4011_RS07885 Genome accession   NZ_AP026968
Coordinates   1522985..1523659 (-) Length   224 a.a.
NCBI ID   WP_000590639.1    Uniprot ID   A0A419RXM2
Organism   Streptococcus parapneumoniae strain SP4011     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1517985..1528659
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP4011_RS07870 (SP4011_15110) - 1520276..1521205 (-) 930 WP_000411189.1 peptidase U32 family protein -
  SP4011_RS07875 (SP4011_15120) - 1521345..1521632 (+) 288 WP_338618659.1 DUF3270 domain-containing protein -
  SP4011_RS07880 (SP4011_15130) ciaH 1521661..1522995 (-) 1335 WP_338618660.1 two-component system sensor histidine kinase CiaH Regulator
  SP4011_RS07885 (SP4011_15140) ciaR 1522985..1523659 (-) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  SP4011_RS07890 (SP4011_15150) - 1523768..1526314 (-) 2547 WP_338618662.1 M1 family metallopeptidase -
  SP4011_RS07895 (SP4011_15160) - 1526437..1526877 (-) 441 WP_338618663.1 ASCH domain-containing protein -
  SP4011_RS07900 (SP4011_15170) - 1526819..1527722 (-) 904 Protein_1510 putative PEP-binding protein -
  SP4011_RS07905 (SP4011_15180) - 1527700..1528200 (-) 501 WP_338618664.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=99127 SP4011_RS07885 WP_000590639.1 1522985..1523659(-) (ciaR) [Streptococcus parapneumoniae strain SP4011]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=99127 SP4011_RS07885 WP_000590639.1 1522985..1523659(-) (ciaR) [Streptococcus parapneumoniae strain SP4011]
ATGATAAAAATCTTATTAGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGGGAAGAAGGTCTTTACGAAGCTGAAAGTGGCGTCTATGATTTGATTTTGCTAGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACTCCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACTAAACCTTTCTACCTAGAAGA
ACTCAAAATGAGGATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAACACCTTGACTTATGGAAATATTGTGG
TTAATTTGTCAACCAATACCGTTAAAGTCGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTTGATTTATTAGTCTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A419RXM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

88.839

100

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment