Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SP4011_RS07880 Genome accession   NZ_AP026968
Coordinates   1521661..1522995 (-) Length   444 a.a.
NCBI ID   WP_338618660.1    Uniprot ID   -
Organism   Streptococcus parapneumoniae strain SP4011     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1516661..1527995
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP4011_RS07865 (SP4011_15100) - 1517626..1520076 (-) 2451 WP_338618657.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  SP4011_RS07870 (SP4011_15110) - 1520276..1521205 (-) 930 WP_000411189.1 peptidase U32 family protein -
  SP4011_RS07875 (SP4011_15120) - 1521345..1521632 (+) 288 WP_338618659.1 DUF3270 domain-containing protein -
  SP4011_RS07880 (SP4011_15130) ciaH 1521661..1522995 (-) 1335 WP_338618660.1 two-component system sensor histidine kinase CiaH Regulator
  SP4011_RS07885 (SP4011_15140) ciaR 1522985..1523659 (-) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  SP4011_RS07890 (SP4011_15150) - 1523768..1526314 (-) 2547 WP_338618662.1 M1 family metallopeptidase -
  SP4011_RS07895 (SP4011_15160) - 1526437..1526877 (-) 441 WP_338618663.1 ASCH domain-containing protein -
  SP4011_RS07900 (SP4011_15170) - 1526819..1527722 (-) 904 Protein_1510 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50701.46 Da        Isoelectric Point: 9.4837

>NTDB_id=99126 SP4011_RS07880 WP_338618660.1 1521661..1522995(-) (ciaH) [Streptococcus parapneumoniae strain SP4011]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEIKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEETYRMILMETNISSVSTN
IKYAAILINTSQLEQASQKHEKLIVIVMASFWIVSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRPIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISTKDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=99126 SP4011_RS07880 WP_338618660.1 1521661..1522995(-) (ciaH) [Streptococcus parapneumoniae strain SP4011]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCAGATGACTTTAGTTATTTTATCCGTAACTTTGGTGTATTCACTCTGAT
TTTCTCTACCATGACTCTGATTATTTTGCAAGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTCCACGGAC
TAAGTGAAAATCCTCAGGCAGTTATTCAGCTTGCTGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAGAATGCCGCT
ACAGATACTAGTAAGACTGAGATAAAACCCAATGTCAGTTCCAATACGGAGGTTATTCTTTTTGATAAGAATTTTACACA
GCTCCTTTCTGGAAATCGATTTTTGGGATTGGATAAGATTAAGTTAGAGAAAAAAGAACTAGGCCATATCTATCAGATTC
AGGTTTTTAATAGCTATGGACAAGAAGAAACCTATCGCATGATCTTGATGGAAACGAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCAGCTATCTTGATTAATACCAGTCAGTTGGAGCAGGCCAGTCAAAAGCACGAGAAATTGATTGTGATTGT
GATGGCAAGTTTCTGGATTGTATCTTTACTTGCAAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGCA
TGCAGAAGCAACAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAGGTCCGAAATAT
GCGTTTTTTGACGACAAACTTGCTGAACTTAGCTCGTAGAGATGATGGGATTAAGCCGGAACTTGCAGAAGTTCCAACTA
GCTTTTTCAATACGACTTTTACAAACTATGAGATGATTGCTTCGGAAAATGATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGTCCGATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTATTTGATAATGCAGTTAAGTATACTGA
AGAGGATGGGGAAATCGATTTTCTTATCTCGGCGACTGATCGCAATCTGTATTTACTTGTTTCTGATAATGGAGTCGGTA
TTTCCACAAAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTGGACAAGGCTAGAACTCGTCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCCTTAAAAGGAACCATTACTGTTAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

95.721

100

0.957
  ciaH Streptococcus pneumoniae D39

95.721

100

0.957
  ciaH Streptococcus pneumoniae R6

95.721

100

0.957
  ciaH Streptococcus pneumoniae TIGR4

95.721

100

0.957
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment