Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   SP4011_RS05265 Genome accession   NZ_AP026968
Coordinates   1021041..1021745 (+) Length   234 a.a.
NCBI ID   WP_050223087.1    Uniprot ID   A0A419RPG7
Organism   Streptococcus parapneumoniae strain SP4011     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1016041..1026745
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP4011_RS05245 (SP4011_09630) coaC 1016279..1016830 (-) 552 WP_112443744.1 phosphopantothenoylcysteine decarboxylase -
  SP4011_RS05250 (SP4011_09640) coaB 1016842..1017531 (-) 690 WP_112443743.1 phosphopantothenate--cysteine ligase -
  SP4011_RS05255 (SP4011_09650) - 1017757..1019427 (+) 1671 WP_338620198.1 formate--tetrahydrofolate ligase -
  SP4011_RS05260 (SP4011_09660) mutY 1019810..1020985 (+) 1176 WP_338620200.1 A/G-specific adenine glycosylase -
  SP4011_RS05265 (SP4011_09670) micA 1021041..1021745 (+) 705 WP_050223087.1 response regulator YycF Regulator
  SP4011_RS05270 (SP4011_09680) micB 1021738..1023087 (+) 1350 WP_000886220.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SP4011_RS05275 (SP4011_09690) vicX 1023089..1023898 (+) 810 WP_000004964.1 MBL fold metallo-hydrolase Regulator
  SP4011_RS05280 (SP4011_09700) relB 1023989..1024231 (+) 243 WP_050223090.1 type II toxin-antitoxin system RelB family antitoxin -
  SP4011_RS05285 (SP4011_09710) - 1024233..1024487 (+) 255 WP_338620205.1 type II toxin-antitoxin system RelE/ParE family toxin -
  SP4011_RS05290 (SP4011_09720) - 1024563..1026440 (+) 1878 WP_338620207.1 Eco57I restriction-modification methylase domain-containing protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26829.66 Da        Isoelectric Point: 4.7209

>NTDB_id=99115 SP4011_RS05265 WP_050223087.1 1021041..1021745(+) (micA) [Streptococcus parapneumoniae strain SP4011]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEAESKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=99115 SP4011_RS05265 WP_050223087.1 1021041..1021745(+) (micA) [Streptococcus parapneumoniae strain SP4011]
ATGAAAAAAATACTAATTGTAGATGATGAAAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
GGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAGCCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGCAAGACCAGCAGTGTGCCTATTATCATGCTGTCGGCT
AAAGACAGTGAATTTGATAAGGTTATCGGTTTGGAGCTTGGGGCTGATGACTATGTAACCAAACCCTTCTCAAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTTTGCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGAAAGTAAACCTC
AGCCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CACCGTGAGTTTGAGCTTTTGTATCATTTGGCATCGCATACAGGTCAAGTCATTACGCGCGAACACTTGCTTGAGACTGT
CTGGGGCTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTCCGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A419RPG7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

99.145

100

0.991
  vicR Streptococcus mutans UA159

78.97

99.573

0.786
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.348

98.291

0.436
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436

Multiple sequence alignment