Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   SP4011_RS05270 Genome accession   NZ_AP026968
Coordinates   1021738..1023087 (+) Length   449 a.a.
NCBI ID   WP_000886220.1    Uniprot ID   -
Organism   Streptococcus parapneumoniae strain SP4011     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1016738..1028087
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP4011_RS05250 (SP4011_09640) coaB 1016842..1017531 (-) 690 WP_112443743.1 phosphopantothenate--cysteine ligase -
  SP4011_RS05255 (SP4011_09650) - 1017757..1019427 (+) 1671 WP_338620198.1 formate--tetrahydrofolate ligase -
  SP4011_RS05260 (SP4011_09660) mutY 1019810..1020985 (+) 1176 WP_338620200.1 A/G-specific adenine glycosylase -
  SP4011_RS05265 (SP4011_09670) micA 1021041..1021745 (+) 705 WP_050223087.1 response regulator YycF Regulator
  SP4011_RS05270 (SP4011_09680) micB 1021738..1023087 (+) 1350 WP_000886220.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SP4011_RS05275 (SP4011_09690) vicX 1023089..1023898 (+) 810 WP_000004964.1 MBL fold metallo-hydrolase Regulator
  SP4011_RS05280 (SP4011_09700) relB 1023989..1024231 (+) 243 WP_050223090.1 type II toxin-antitoxin system RelB family antitoxin -
  SP4011_RS05285 (SP4011_09710) - 1024233..1024487 (+) 255 WP_338620205.1 type II toxin-antitoxin system RelE/ParE family toxin -
  SP4011_RS05290 (SP4011_09720) - 1024563..1026440 (+) 1878 WP_338620207.1 Eco57I restriction-modification methylase domain-containing protein -
  SP4011_RS05295 (SP4011_09730) - 1026550..1027500 (+) 951 WP_000658133.1 Abi family protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51631.13 Da        Isoelectric Point: 4.7177

>NTDB_id=99116 SP4011_RS05270 WP_000886220.1 1021738..1023087(+) (micB) [Streptococcus parapneumoniae strain SP4011]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIRLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILEVLKIEEDYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDQIRGQDEEKKYELVRDYPITSVW
IEIDTDKMTQVIDNILNNAIKYSPDGGKITVTMKTTDDQMILSISDQGLGIPKQDLPRIFDRFYRVDRARSRSQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=99116 SP4011_RS05270 WP_000886220.1 1021738..1023087(+) (micB) [Streptococcus parapneumoniae strain SP4011]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACTCTCCTATTACTAGAGAATAGACGTGATAATATTCGATTGAAGCAAATCAATCAAAAGGTTAAAGACTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGACTAAATAGTATTCTGTTTTATATGACAGATGGGGT
CCTTGCGACCAATCGTCGGGGGCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAAGAAGATG
TCCTGAATAGAAGCATTTTGGAAGTACTCAAGATAGAAGAAGACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGACATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGCTACGGACACCCTTAACCAGTGTTAAATCTTATCTTGAAGCCTTGGATGAGGGAGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAAACCAACCGTATGATGCGCATGGTGACGGACCTCCTTCA
TCTTTCACGGATTGATAACGCGACCAGTCATCTGGATGTGGAACTGATTAACTTTACTGCCTTTATTACCTTTATCCTCA
ACCGTTTTGATCAGATAAGAGGGCAGGATGAAGAGAAGAAATACGAACTGGTGAGAGATTACCCCATTACCTCAGTCTGG
ATAGAGATAGATACAGATAAGATGACACAGGTGATTGATAATATTCTCAACAATGCCATCAAGTATTCGCCAGATGGTGG
GAAAATCACAGTGACCATGAAGACGACTGATGATCAGATGATTTTATCCATTTCAGACCAGGGATTGGGGATTCCCAAGC
AGGATTTACCACGTATTTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTTCCCAAGGTGGTACAGGTCTAGGA
CTGTCTATTGCCAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGTAAGGGATCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTGTGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

96.128

97.773

0.94
  vicK Streptococcus mutans UA159

71.393

89.532

0.639

Multiple sequence alignment