Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   SP4011_RS00405 Genome accession   NZ_AP026968
Coordinates   67150..68499 (+) Length   449 a.a.
NCBI ID   WP_338619439.1    Uniprot ID   -
Organism   Streptococcus parapneumoniae strain SP4011     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 62150..73499
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP4011_RS00355 (SP4011_00630) - 62297..62425 (+) 129 WP_000658223.1 smi_0059.1 family bacteriocin-like peptide -
  SP4011_RS00360 (SP4011_00640) - 62437..62592 (+) 156 WP_001004584.1 hypothetical protein -
  SP4011_RS00365 (SP4011_00650) - 62627..62821 (+) 195 WP_000180815.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SP4011_RS00370 (SP4011_00660) - 62849..63049 (+) 201 WP_000478865.1 hypothetical protein -
  SP4011_RS00375 (SP4011_00670) - 63058..63225 (+) 168 WP_173219503.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SP4011_RS00380 (SP4011_00680) - 63229..63444 (+) 216 WP_240147170.1 bacteriocin immunity protein -
  SP4011_RS00385 (SP4011_00690) - 63525..63704 (+) 180 WP_173283047.1 hypothetical protein -
  SP4011_RS00390 (SP4011_00700) - 63782..63988 (+) 207 WP_173283045.1 bacteriocin immunity protein -
  SP4011_RS00395 - 64485..64673 (+) 189 WP_338619437.1 hypothetical protein -
  SP4011_RS00400 (SP4011_00710) comA 64984..67137 (+) 2154 WP_338619438.1 peptide cleavage/export ABC transporter ComA Regulator
  SP4011_RS00405 (SP4011_00720) comB 67150..68499 (+) 1350 WP_338619439.1 competence pheromone export protein ComB Regulator
  SP4011_RS00410 (SP4011_00730) purC 68669..69376 (+) 708 WP_338619440.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SP4011_RS00415 - 69378..69521 (+) 144 WP_338620379.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  SP4011_RS00420 (SP4011_00740) - 69578..73303 (+) 3726 WP_338619441.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49948.86 Da        Isoelectric Point: 5.2614

>NTDB_id=99076 SP4011_RS00405 WP_338619439.1 67150..68499(+) (comB) [Streptococcus parapneumoniae strain SP4011]
MKPEFLESAEFYNRRYHNFSSRVIVPMSLLLVFLLGFATFAEKEMSLFTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGELLVQYQEGSEGVQAEAYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYLSQAASLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGTSLASQNLAYSLYQSYKSQGEENPQAKAQAVAQVEAQLS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLDQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSTMVAEGTLLAQLYPSLEKEGKAKLTAYLSSKDVARIKVGDSVRYTTTHDANNQLFLDSTITSIDATATKTEK
GNFFKIEAETDLTVEQAERLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=99076 SP4011_RS00405 WP_338619439.1 67150..68499(+) (comB) [Streptococcus parapneumoniae strain SP4011]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTCGGGTGATTGTACCCAT
GTCCCTTCTGCTCGTGTTTTTGCTTGGCTTTGCAACATTTGCAGAGAAGGAGATGAGTTTGTTTACTAGAGCTACTGTTG
AGCCTAGTCGAATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGTTG
GTCAAGAAGGGGGAGCTTCTTGTTCAATATCAGGAAGGGTCAGAGGGTGTCCAAGCGGAGGCCTATGCTAGTCAGTTGGA
CATGCTTAAGGATCAAAAAAAGCAATTGGAGTATTTGCAAAAAAGTCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACCTCAGCCAAGCGGCTAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCTGAAATCGGCAACCTCATCAGCCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGCACTTCCTTGGCCAGTCAGAATCTAGCCTACTCTCTCT
ACCAGTCCTACAAGTCTCAGGGGGAGGAAAATCCGCAAGCTAAGGCACAAGCAGTTGCGCAGGTTGAAGCACAGCTTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTTCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCTTCAGGCTTAAG
CAGTCAATTGGAGTCCCTTAAATCCCAACACTTAGCAAAGGTTGGTCAGGAATTGACCCTTCTAGACCAGAAAATCTTGG
AAGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTACCATGGTAGCAGAGGGGACTCTACTAGCCCAACTCTATCCGTCCTTGGAAAAAGA
AGGGAAAGCTAAACTAACAGCTTATCTTAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACGA
CGACTCATGATGCCAATAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACCAAGACTGAAAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACAGATCTGACTGTTGAGCAGGCTGAAAGACTTCGATATGGGGTGGAAGGCCG
CCTACAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains

Predicted by InterproScan.

HlyD family secretion protein (HlyD_3)

(310-423)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mitis SK321

96.214

100

0.962
  comB Streptococcus pneumoniae Rx1

95.323

100

0.953
  comB Streptococcus pneumoniae D39

95.323

100

0.953
  comB Streptococcus pneumoniae R6

95.323

100

0.953
  comB Streptococcus pneumoniae TIGR4

94.655

100

0.947
  comB Streptococcus mitis NCTC 12261

94.655

100

0.947
  comB Streptococcus gordonii str. Challis substr. CH1

56

100

0.561

Multiple sequence alignment