Detailed information NTG0099075

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: SP4011_RS00400
• Genome accession: NZ_AP026968
• Coordinates: 64984..67137 (+)
• Length: 717 a.a.
• NCBI ID: WP_338619438.1
• Uniprot ID: -
• Organism: Streptococcus parapneumoniae strain SP4011
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 59984..72137

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP4011_RS00345 (SP4011_00610)	-	60259..61074 (+)	816	WP_338619435.1	GHKL domain-containing protein	-
SP4011_RS00350 (SP4011_00620)	-	61071..61802 (+)	732	WP_001221867.1	response regulator transcription factor	-
SP4011_RS00355 (SP4011_00630)	-	62297..62425 (+)	129	WP_000658223.1	smi_0059.1 family bacteriocin-like peptide	-
SP4011_RS00360 (SP4011_00640)	-	62437..62592 (+)	156	WP_001004584.1	hypothetical protein	-
SP4011_RS00365 (SP4011_00650)	-	62627..62821 (+)	195	WP_000180815.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SP4011_RS00370 (SP4011_00660)	-	62849..63049 (+)	201	WP_000478865.1	hypothetical protein	-
SP4011_RS00375 (SP4011_00670)	-	63058..63225 (+)	168	WP_173219503.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SP4011_RS00380 (SP4011_00680)	-	63229..63444 (+)	216	WP_240147170.1	bacteriocin immunity protein	-
SP4011_RS00385 (SP4011_00690)	-	63525..63704 (+)	180	WP_173283047.1	hypothetical protein	-
SP4011_RS00390 (SP4011_00700)	-	63782..63988 (+)	207	WP_173283045.1	bacteriocin immunity protein	-
SP4011_RS00395	-	64485..64673 (+)	189	WP_338619437.1	hypothetical protein	-
SP4011_RS00400 (SP4011_00710)	comA	64984..67137 (+)	2154	WP_338619438.1	peptide cleavage/export ABC transporter ComA	Regulator
SP4011_RS00405 (SP4011_00720)	comB	67150..68499 (+)	1350	WP_338619439.1	competence pheromone export protein ComB	Regulator
SP4011_RS00410 (SP4011_00730)	purC	68669..69376 (+)	708	WP_338619440.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
SP4011_RS00415	-	69378..69521 (+)	144	WP_338620379.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80263.31 Da
• Isoelectric Point: 6.3889

>NTDB_id=99075 SP4011_RS00400 WP_338619438.1 64984..67137(+) (comA) [Streptococcus parapneumoniae strain SP4011]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESSRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVYYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=99075 SP4011_RS00400 WP_338619438.1 64984..67137(+) (comA) [Streptococcus parapneumoniae strain SP4011]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACAACCATGGATGGGACAACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTCTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTTCTTAAGGAAGGAAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTTGGGATTATTTCTATTGGGCTGGTTA
TCGTCTATATTCTCCAGCAGATTTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACTTGCCCATGTCCTTCTTTGCGACACGCAGAACAGGGGAAATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATTGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACCTTATTGGCGCTGCCTATCTACACAGTG
ATTATCTTTGCTTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAATGGTATTGAGACTATCAAGTCTTTGACCAGTGAAAGTTCACGCTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGTAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAACCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAGGTTTATCTGGTAGCTTCGGAGTTTGAGGAGAAGAAAACGGTTGAGGATTTGAGTTTGATG
AAGGGAGAGATGACTTTCAAGCAAGTTTACTACAAGTATGGCTATGGTCGAGATGTCTTGTCAGACATCAATTTGACCAT
TCCCCAAGGCTCTAAGGTGGCTTTTGTGGGAATTTCGGGGTCAGGTAAGACGACCTTGGCCAAGATGATGGTTAATTTTT
ACGATCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTAGAGAATCTTCTCCTTGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGATATCGAGCGCATGCCTCTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATCTCAGGTGGTCAACGTCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGACGAGGCGACCAGCAGTTTAGATATTTTGACAGAGAAGCGAATTGTCGATAATCTGATGGCTTT
AGACAAGACCTTGATTTTCATCGCCCACCGCTTGACCATTGCTGAGCGGACAGAGAAGGTGGTTGTTTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGATTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis SK321	99.163	100	0.992
comA	Streptococcus mitis NCTC 12261	99.024	100	0.99
comA	Streptococcus pneumoniae Rx1	98.745	100	0.987
comA	Streptococcus pneumoniae D39	98.745	100	0.987
comA	Streptococcus pneumoniae R6	98.745	100	0.987
comA	Streptococcus pneumoniae TIGR4	98.326	100	0.983
comA	Streptococcus gordonii str. Challis substr. CH1	80.614	100	0.806
comA/nlmT	Streptococcus mutans UA159	65.132	100	0.651