Detailed information NTG0098276

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8635_RS08705
• Genome accession: NZ_AP026924
• Coordinates: 1682442..1683179 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain PZ900700063
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1677442..1688179

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8635_RS08685 (PC0062_17260)	comA/nlmT	1677817..1679460 (+)	1644	WP_317657564.1	peptide cleavage/export ABC transporter	Regulator
R8635_RS08690 (PC0062_17280)	-	1679471..1680832 (+)	1362	Protein_1727	bacteriocin secretion accessory protein	-
R8635_RS08695 (PC0062_17290)	blpC	1680889..1681017 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8635_RS08700 (PC0062_17300)	-	1681088..1682428 (-)	1341	WP_001017646.1	sensor histidine kinase	-
R8635_RS08705 (PC0062_17310)	comE/blpR	1682442..1683179 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
R8635_RS08710 (PC0062_17320)	-	1683184..1683522 (-)	339	WP_000682120.1	LytTR family DNA-binding domain-containing protein	-
R8635_RS08715 (PC0062_17330)	-	1683799..1684128 (+)	330	WP_000132572.1	hypothetical protein	-
R8635_RS08720 (PC0062_17340)	-	1684296..1685345 (-)	1050	WP_000653771.1	ABC transporter permease	-
R8635_RS08725 (PC0062_17350)	pptA	1685342..1686073 (-)	732	WP_001866897.1	ABC transporter ATP-binding protein	Regulator
R8635_RS08730 (PC0062_17360)	-	1686141..1686551 (+)	411	WP_001278301.1	HIT family protein	-
R8635_RS08735 (PC0062_17370)	-	1686561..1686848 (+)	288	WP_268217887.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=98276 R8635_RS08705 WP_001219120.1 1682442..1683179(-) (comE/blpR) [Streptococcus pneumoniae strain PZ900700063]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=98276 R8635_RS08705 WP_001219120.1 1682442..1683179(-) (comE/blpR) [Streptococcus pneumoniae strain PZ900700063]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363