Detailed information NTG0097920

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: R8613_RS11205
• Genome accession: NZ_AP026919
• Coordinates: 2142985..2143737 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700012
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2137985..2148737

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8613_RS11185	-	2140459..2142021 (-)	1563	Protein_2175	YhgE/Pip family protein	-
R8613_RS11190 (PC0012_21460)	-	2142200..2142742 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
R8613_RS11205 (PC0012_21470)	comE	2142985..2143737 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
R8613_RS11210 (PC0012_21480)	comD/comD1	2143734..2145059 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
R8613_RS11215 (PC0012_21490)	comC/comC1	2145080..2145205 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
R8613_RS11225 (PC0012_21500)	rlmH	2145487..2145966 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
R8613_RS11230 (PC0012_21510)	htrA	2146149..2147330 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
R8613_RS11235 (PC0012_21520)	spo0J	2147388..2148146 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=97920 R8613_RS11205 WP_000866065.1 2142985..2143737(-) (comE) [Streptococcus pneumoniae strain PZ900700012]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=97920 R8613_RS11205 WP_000866065.1 2142985..2143737(-) (comE) [Streptococcus pneumoniae strain PZ900700012]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408