Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R8619_RS02470 Genome accession   NZ_AP026918
Coordinates   476526..477263 (+) Length   245 a.a.
NCBI ID   WP_001219143.1    Uniprot ID   A0A0U0IWP6
Organism   Streptococcus pneumoniae strain PZ900700009     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 471526..482263
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8619_RS02440 (PC0009_04730) - 472859..473146 (-) 288 WP_000777760.1 hypothetical protein -
  R8619_RS02445 (PC0009_04740) - 473156..473566 (-) 411 WP_001278301.1 HIT family protein -
  R8619_RS02450 (PC0009_04750) pptA 473634..474365 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  R8619_RS02455 (PC0009_04760) - 474362..475411 (+) 1050 WP_000653773.1 ABC transporter permease -
  R8619_RS02460 (PC0009_04770) - 475578..475907 (-) 330 WP_000132572.1 hypothetical protein -
  R8619_RS02465 (PC0009_04780) - 476183..476521 (+) 339 WP_000682126.1 LytTR family DNA-binding domain-containing protein -
  R8619_RS02470 (PC0009_04790) comE/blpR 476526..477263 (+) 738 WP_001219143.1 response regulator transcription factor Regulator
  R8619_RS02475 (PC0009_04800) - 477277..478617 (+) 1341 WP_001028651.1 sensor histidine kinase -
  R8619_RS02480 (PC0009_04810) blpC 478662..478817 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  R8619_RS02485 (PC0009_04820) - 478874..480235 (-) 1362 WP_001069081.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28812.93 Da        Isoelectric Point: 6.2366

>NTDB_id=97781 R8619_RS02470 WP_001219143.1 476526..477263(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700009]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=97781 R8619_RS02470 WP_001219143.1 476526..477263(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700009]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCTCGTCTTTTGCAGTGCCATCGCTCCTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGAGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0IWP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment