Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   R8522_RS11440 Genome accession   NZ_AP026916
Coordinates   2225674..2226855 (+) Length   393 a.a.
NCBI ID   WP_000681601.1    Uniprot ID   A0A0B7LRW6
Organism   Streptococcus pneumoniae strain PZ900700006     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2220674..2231855
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8522_RS11405 (PC0006_22560) adcR 2221005..2221445 (+) 441 WP_001249309.1 zinc-dependent transcriptional regulator AdcR -
  R8522_RS11410 (PC0006_22570) - 2221445..2222149 (+) 705 WP_001269488.1 metal ABC transporter ATP-binding protein -
  R8522_RS11415 (PC0006_22580) - 2222142..2222948 (+) 807 WP_000950018.1 metal ABC transporter permease -
  R8522_RS11420 (PC0006_22590) adcA 2222958..2224463 (+) 1506 WP_050123039.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
  R8522_RS11425 comC/comC2 2224605..2224730 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  R8522_RS11435 (PC0006_22600) rlmH 2225012..2225491 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R8522_RS11440 (PC0006_22610) htrA 2225674..2226855 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  R8522_RS11445 (PC0006_22620) spo0J 2226913..2227671 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41855.70 Da        Isoelectric Point: 6.8902

>NTDB_id=97690 R8522_RS11440 WP_000681601.1 2225674..2226855(+) (htrA) [Streptococcus pneumoniae strain PZ900700006]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=97690 R8522_RS11440 WP_000681601.1 2225674..2226855(+) (htrA) [Streptococcus pneumoniae strain PZ900700006]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LRW6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.491

100

0.995
  htrA Streptococcus pneumoniae D39

99.491

100

0.995
  htrA Streptococcus pneumoniae R6

99.491

100

0.995
  htrA Streptococcus pneumoniae TIGR4

99.491

100

0.995
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.919

100

0.674
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment