Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   R8522_RS11425 Genome accession   NZ_AP026916
Coordinates   2224605..2224730 (-) Length   41 a.a.
NCBI ID   WP_000799686.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain PZ900700006     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2219605..2229730
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8522_RS11405 (PC0006_22560) adcR 2221005..2221445 (+) 441 WP_001249309.1 zinc-dependent transcriptional regulator AdcR -
  R8522_RS11410 (PC0006_22570) - 2221445..2222149 (+) 705 WP_001269488.1 metal ABC transporter ATP-binding protein -
  R8522_RS11415 (PC0006_22580) - 2222142..2222948 (+) 807 WP_000950018.1 metal ABC transporter permease -
  R8522_RS11420 (PC0006_22590) adcA 2222958..2224463 (+) 1506 WP_050123039.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
  R8522_RS11425 comC/comC2 2224605..2224730 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  R8522_RS11435 (PC0006_22600) rlmH 2225012..2225491 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R8522_RS11440 (PC0006_22610) htrA 2225674..2226855 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  R8522_RS11445 (PC0006_22620) spo0J 2226913..2227671 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4907.00 Da        Isoelectric Point: 11.0006

>NTDB_id=97689 R8522_RS11425 WP_000799686.1 2224605..2224730(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700006]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=97689 R8522_RS11425 WP_000799686.1 2224605..2224730(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700006]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

100

100

1
  comC/comC2 Streptococcus pneumoniae TIGR4

100

100

1
  comC/comC1 Streptococcus pneumoniae R6

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae G54

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae D39

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae Rx1

80.488

100

0.805
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

57.5

97.561

0.561

Multiple sequence alignment