Detailed information NTG0097496

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R8474_RS07660
• Genome accession: NZ_AP026914
• Coordinates: 1511707..1512294 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900700003
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1506707..1517294

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8474_RS07620 (PC0003_15090)	-	1506814..1507172 (-)	359	Protein_1508	immunity protein	-
R8474_RS07625	-	1507653..1507772 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R8474_RS10700	-	1507775..1507840 (-)	66	Protein_1510	ComC/BlpC family peptide pheromone/bacteriocin	-
R8474_RS07630 (PC0003_15110)	cipB	1507876..1508025 (-)	150	WP_001820573.1	bacteriocin-like peptide BlpO	Regulator
R8474_RS07635 (PC0003_15120)	blpN	1508269..1508472 (-)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
R8474_RS07640 (PC0003_15130)	blpM	1508488..1508742 (-)	255	WP_000379877.1	two-peptide bacteriocin subunit BlpM	-
R8474_RS07645	-	1508895..1509699 (-)	805	Protein_1514	IS5 family transposase	-
R8474_RS07650 (PC0003_15170)	-	1510702..1510896 (-)	195	WP_050150399.1	hypothetical protein	-
R8474_RS07655 (PC0003_15180)	-	1511214..1511417 (-)	204	WP_001093272.1	bacteriocin class II family protein	-
R8474_RS07660 (PC0003_15190)	comA/nlmT	1511707..1512294 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R8474_RS07665 (PC0003_15200)	-	1512221..1513864 (+)	1644	Protein_1518	peptide cleavage/export ABC transporter	-
R8474_RS07670 (PC0003_15220)	-	1513875..1515236 (+)	1362	WP_317641666.1	bacteriocin secretion accessory protein	-
R8474_RS07675 (PC0003_15230)	blpC	1515293..1515421 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8474_RS07680 (PC0003_15240)	-	1515492..1516832 (-)	1341	WP_001017646.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=97496 R8474_RS07660 WP_000205166.1 1511707..1512294(+) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700003]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=97496 R8474_RS07660 WP_000205166.1 1511707..1512294(+) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700003]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497