Detailed information NTG0969722

Bioinformatically predicted

Overview

• Name: comR/comR1
• Type: Regulator
• Locus tag: ACJWMC_RS06505
• Genome accession: NZ_CP177181
• Coordinates: 1322045..1322950 (+)
• Length: 301 a.a.
• NCBI ID: WP_002891217.1
• Uniprot ID: J7TIP3
• Organism: Streptococcus salivarius strain MRD1919
• Function: repress natural transformation (predicted from homology) Competence regulation

Genomic Context

Location: 1317045..1327950

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACJWMC_RS06480	-	1317531..1318451 (-)	921	WP_002891211.1	multidrug resistance efflux transporter family protein	-
ACJWMC_RS06485	-	1318606..1319127 (-)	522	WP_224111181.1	RDD family protein	-
ACJWMC_RS06490	comR	1319345..1320253 (+)	909	WP_002891213.1	helix-turn-helix domain-containing protein	Regulator
ACJWMC_RS06495	-	1320339..1321175 (+)	837	WP_002891214.1	ABC transporter ATP-binding protein	-
ACJWMC_RS06500	-	1321168..1321887 (+)	720	WP_002891215.1	ABC transporter permease	-
ACJWMC_RS06505	comR/comR1	1322045..1322950 (+)	906	WP_002891217.1	helix-turn-helix domain-containing protein	Regulator
ACJWMC_RS06510	-	1323063..1323950 (-)	888	WP_002891218.1	hypothetical protein	-
ACJWMC_RS06515	-	1324322..1324783 (-)	462	WP_037597934.1	GNAT family N-acetyltransferase	-
ACJWMC_RS06520	-	1324822..1325607 (-)	786	WP_002891220.1	ABC transporter permease	-
ACJWMC_RS06525	-	1325609..1326427 (-)	819	WP_037597935.1	ABC transporter permease	-
ACJWMC_RS06530	-	1326429..1327421 (-)	993	WP_002891222.1	ATP-binding cassette domain-containing protein	-

Sequence

Protein

• Length: 301 a.a.
• Molecular weight: 35586.98 Da
• Isoelectric Point: 4.5336

>NTDB_id=969722 ACJWMC_RS06505 WP_002891217.1 1322045..1322950(+) (comR/comR1) [Streptococcus salivarius strain MRD1919]
MSDDIKIEIGKRIREERERIGLTREQVCDTEEELTVKQLMRIELGRSLPTIVKLQYISDKLGVSLNYLLGETKLDIPEDY
YKAKYKLMKSPVYGDPERIKKKLKDIEELYDNYIDILPEDELFAIDIIERTLNFMVMEEDSLIESVFEDYLTQALKKEAY
SLNDLLLISYYALRCQDYDYDKGIIDEFRRKLIKQELQGEELFNIELMGALTSIAGIYVMHHDYKDMKSVVDKLYEIMHS
CMQHSYQPGIIVFEAKYYLFYENNREKATELYHTATLLAEAFGDQVFIKNLKMEIEKDLNI

Nucleotide

• Length: 906 bp

>NTDB_id=969722 ACJWMC_RS06505 WP_002891217.1 1322045..1322950(+) (comR/comR1) [Streptococcus salivarius strain MRD1919]
ATGTCTGATGATATTAAAATCGAGATTGGAAAAAGAATTCGTGAAGAACGTGAACGAATAGGTTTAACACGTGAGCAGGT
TTGTGACACAGAAGAAGAATTAACCGTCAAACAACTGATGAGAATTGAGCTCGGTCGCTCATTACCAACTATTGTCAAAC
TGCAGTATATCAGTGATAAATTGGGAGTTTCCCTAAACTATTTGCTAGGTGAAACAAAACTAGACATTCCTGAAGACTAT
TACAAGGCTAAATATAAACTCATGAAGTCTCCTGTCTATGGCGACCCGGAACGTATCAAGAAGAAGCTAAAAGATATTGA
GGAACTCTACGACAACTATATTGATATTCTACCAGAGGACGAGCTTTTTGCTATTGATATCATTGAAAGAACGTTAAATT
TTATGGTTATGGAAGAAGATAGTCTTATTGAATCTGTATTTGAAGACTATTTGACTCAAGCTTTGAAAAAAGAAGCATAT
TCCTTAAATGACCTTCTATTAATTTCATACTATGCATTACGATGTCAGGATTATGACTATGATAAAGGAATAATTGACGA
ATTTAGACGTAAATTAATTAAGCAAGAATTGCAAGGTGAAGAGCTGTTTAATATTGAATTAATGGGAGCTCTAACATCTA
TAGCTGGTATTTACGTCATGCATCATGACTATAAAGACATGAAATCTGTTGTAGATAAATTGTATGAGATTATGCATTCA
TGTATGCAACATTCCTATCAACCAGGTATCATAGTTTTTGAAGCAAAATACTATCTCTTCTATGAGAACAATAGAGAAAA
AGCAACAGAGCTCTATCATACAGCTACCCTACTAGCCGAAGCTTTTGGTGACCAAGTCTTCATCAAAAATCTTAAAATGG
AAATTGAAAAAGATTTAAACATATAA

Domains

Predicted by InterProScan.

• ComR tetratricopeptide (ComR_TPR) (77-294)

3D structure

• AlphaFold DB: J7TIP3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	38.983	98.007	0.382
comR	Streptococcus thermophilus LMG 18311	39.31	96.346	0.379
comR	Streptococcus thermophilus LMD-9	38.966	96.346	0.375
comR	Streptococcus salivarius strain HSISS4	38.966	96.346	0.375
comR	Streptococcus salivarius SK126	39.085	94.352	0.369
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	37.457	96.678	0.362