Detailed information NTG0095349

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: QMM10_RS04895
• Genome accession: NZ_AP025938
• Coordinates: 959195..959899 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain PZ900701057
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 954195..964899

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMM10_RS04870 (PC1044_09570)	coaC	954485..955036 (-)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-
QMM10_RS04875 (PC1044_09580)	coaB	955048..955737 (-)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
QMM10_RS04880 (PC1044_09590)	-	955967..957637 (+)	1671	WP_000845273.1	formate--tetrahydrofolate ligase	-
QMM10_RS04885	-	957743..957868 (-)	126	WP_001818232.1	hypothetical protein	-
QMM10_RS04890 (PC1044_09600)	mutY	957965..959140 (+)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
QMM10_RS04895 (PC1044_09610)	micA	959195..959899 (+)	705	WP_000722076.1	response regulator YycF	Regulator
QMM10_RS04900 (PC1044_09620)	micB	959892..961241 (+)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
QMM10_RS04905 (PC1044_09630)	vicX	961243..962052 (+)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
QMM10_RS04910 (PC1044_09640)	-	962143..962385 (+)	243	WP_000208080.1	DUF6290 family protein	-
QMM10_RS04915 (PC1044_09650)	-	962387..962641 (+)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
QMM10_RS04920 (PC1044_09660)	-	962716..964587 (+)	1872	WP_000150986.1	Eco57I restriction-modification methylase domain-containing protein	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=95349 QMM10_RS04895 WP_000722076.1 959195..959899(+) (micA) [Streptococcus pneumoniae strain PZ900701057]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=95349 QMM10_RS04895 WP_000722076.1 959195..959899(+) (micA) [Streptococcus pneumoniae strain PZ900701057]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38