Detailed information NTG0095325

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: QML92_RS10410
• Genome accession: NZ_AP025937
• Coordinates: 2043558..2043683 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain PZ900700792
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2038558..2048683

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QML92_RS10380	-	2038939..2040550 (-)	1612	Protein_2017	YhgE/Pip domain-containing protein	-
QML92_RS10385 (PC0780_20190)	-	2040678..2041220 (+)	543	WP_001158263.1	TetR/AcrR family transcriptional regulator	-
QML92_RS10400 (PC0780_20200)	comE	2041463..2042215 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
QML92_RS10405 (PC0780_20210)	comD/comD2	2042212..2043537 (-)	1326	WP_001842237.1	competence system sensor histidine kinase ComD	Regulator
QML92_RS10410	comC/comC2	2043558..2043683 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
QML92_RS10420 (PC0780_20220)	rlmH	2043965..2044444 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QML92_RS10425 (PC0780_20230)	htrA	2044627..2045808 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
QML92_RS10430 (PC0780_20240)	spo0J	2045866..2046624 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=95325 QML92_RS10410 WP_000799686.1 2043558..2043683(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700792]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=95325 QML92_RS10410 WP_000799686.1 2043558..2043683(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700792]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561