Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   QML92_RS10405 Genome accession   NZ_AP025937
Coordinates   2042212..2043537 (-) Length   441 a.a.
NCBI ID   WP_001842237.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700792     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2037212..2048537
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QML92_RS10380 - 2038939..2040550 (-) 1612 Protein_2017 YhgE/Pip domain-containing protein -
  QML92_RS10385 (PC0780_20190) - 2040678..2041220 (+) 543 WP_001158263.1 TetR/AcrR family transcriptional regulator -
  QML92_RS10400 (PC0780_20200) comE 2041463..2042215 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  QML92_RS10405 (PC0780_20210) comD/comD2 2042212..2043537 (-) 1326 WP_001842237.1 competence system sensor histidine kinase ComD Regulator
  QML92_RS10410 comC/comC2 2043558..2043683 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  QML92_RS10420 (PC0780_20220) rlmH 2043965..2044444 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  QML92_RS10425 (PC0780_20230) htrA 2044627..2045808 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  QML92_RS10430 (PC0780_20240) spo0J 2045866..2046624 (+) 759 WP_000410380.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51441.05 Da        Isoelectric Point: 7.5816

>NTDB_id=95324 QML92_RS10405 WP_001842237.1 2042212..2043537(-) (comD/comD2) [Streptococcus pneumoniae strain PZ900700792]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=95324 QML92_RS10405 WP_001842237.1 2042212..2043537(-) (comD/comD2) [Streptococcus pneumoniae strain PZ900700792]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.546

100

0.995
  comD/comD1 Streptococcus pneumoniae Rx1

96.825

100

0.968
  comD/comD1 Streptococcus pneumoniae D39

96.825

100

0.968
  comD/comD1 Streptococcus pneumoniae R6

96.825

100

0.968
  comD Streptococcus mitis SK321

92.063

100

0.921
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419

Multiple sequence alignment