Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   AAA982_RS00450 Genome accession   NZ_AP028601
Coordinates   76145..78298 (+) Length   717 a.a.
NCBI ID   WP_338168296.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PF1     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 71145..83298
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAA982_RS00415 (TKY113292_00770) - 71496..72665 (+) 1170 WP_338168295.1 pyridoxal phosphate-dependent aminotransferase -
  AAA982_RS00420 (TKY113292_00780) recO 72662..73432 (+) 771 WP_000616162.1 DNA repair protein RecO Machinery gene
  AAA982_RS00425 (TKY113292_00790) plsX 73429..74421 (+) 993 WP_050311686.1 phosphate acyltransferase PlsX -
  AAA982_RS00430 (TKY113292_00800) - 74427..74660 (+) 234 WP_000659556.1 acyl carrier protein -
  AAA982_RS00435 - 74706..74997 (+) 292 Protein_79 IS5/IS1182 family transposase -
  AAA982_RS00440 blpU 75200..75430 (+) 231 Protein_80 bacteriocin-like peptide BlpU -
  AAA982_RS00445 (TKY113292_00810) - 75433..75558 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  AAA982_RS00450 (TKY113292_00820) comA 76145..78298 (+) 2154 WP_338168296.1 peptide cleavage/export ABC transporter ComA Regulator
  AAA982_RS00455 (TKY113292_00830) comB 78311..79660 (+) 1350 WP_338168297.1 competence pheromone export protein ComB Regulator
  AAA982_RS00460 (TKY113292_00840) purC 79830..80537 (+) 708 WP_000043300.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  AAA982_RS00465 - 80548..80682 (+) 135 WP_000429436.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80340.35 Da        Isoelectric Point: 6.3370

>NTDB_id=94961 AAA982_RS00450 WP_338168296.1 76145..78298(+) (comA) [Streptococcus pneumoniae strain PF1]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=94961 AAA982_RS00450 WP_338168296.1 76145..78298(+) (comA) [Streptococcus pneumoniae strain PF1]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTCATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGGGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGTTGGGGATTATTTCTATTGGGCTGGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCAATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCATTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAATGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTGGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGAGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterProScan.

ABC transporter transmembrane region (ABC_membrane)

(170-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.582

100

0.996
  comA Streptococcus pneumoniae D39

99.582

100

0.996
  comA Streptococcus pneumoniae R6

99.582

100

0.996
  comA Streptococcus pneumoniae TIGR4

99.163

100

0.992
  comA Streptococcus mitis SK321

98.605

100

0.986
  comA Streptococcus mitis NCTC 12261

98.466

100

0.985
  comA Streptococcus gordonii str. Challis substr. CH1

80.614

100

0.806
  comA/nlmT Streptococcus mutans UA159

64.714

100

0.647