Detailed information NTG0940849

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: V6U70_RS05690
• Genome accession: NZ_CP145868
• Coordinates: 1177196..1177870 (-)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus salivarius strain KSS12
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1172196..1182870

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V6U70_RS05665 (V6U70_05660)	-	1172510..1173787 (-)	1278	WP_410532149.1	pyrimidine-nucleoside phosphorylase	-
V6U70_RS05670 (V6U70_05665)	-	1173784..1174374 (-)	591	WP_410532150.1	class I SAM-dependent methyltransferase	-
V6U70_RS05675 (V6U70_05670)	coaA	1174487..1175407 (+)	921	WP_013990467.1	type I pantothenate kinase	-
V6U70_RS05680 (V6U70_05675)	rpsT	1175477..1175713 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
V6U70_RS05685 (V6U70_05680)	ciaH	1175791..1177206 (-)	1416	WP_410532152.1	sensor histidine kinase	Regulator
V6U70_RS05690 (V6U70_05685)	ciaR	1177196..1177870 (-)	675	WP_002891134.1	response regulator transcription factor	Regulator
V6U70_RS05695 (V6U70_05690)	-	1178069..1179739 (-)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
V6U70_RS05700 (V6U70_05695)	-	1179934..1180617 (+)	684	WP_002891136.1	phosphopantothenate--cysteine ligase	-
V6U70_RS05705 (V6U70_05700)	coaC	1180610..1181155 (+)	546	WP_021144029.1	phosphopantothenoylcysteine decarboxylase	-
V6U70_RS05710 (V6U70_05705)	-	1181184..1181756 (+)	573	WP_021144028.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=940849 V6U70_RS05690 WP_002891134.1 1177196..1177870(-) (ciaR) [Streptococcus salivarius strain KSS12]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=940849 V6U70_RS05690 WP_002891134.1 1177196..1177870(-) (ciaR) [Streptococcus salivarius strain KSS12]
ATGATTAAAATACTACTAGTAGAAGATGATTTAAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTAATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362