Detailed information NTG0940753

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: V6U69_RS00020
• Genome accession: NZ_CP145867
• Coordinates: 3559..4794 (-)
• Length: 411 a.a.
• NCBI ID: WP_002892211.1
• Uniprot ID: J7SI15
• Organism: Streptococcus salivarius strain KSS10
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1..9794

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V6U69_RS00010 (V6U69_00010)	dnaA	1124..2488 (-)	1365	WP_037599382.1	chromosomal replication initiator protein DnaA	-
V6U69_RS00015 (V6U69_00015)	spo0J	2726..3493 (-)	768	WP_195435977.1	ParB/RepB/Spo0J family partition protein	Regulator
V6U69_RS00020 (V6U69_00020)	htrA	3559..4794 (-)	1236	WP_002892211.1	S1C family serine protease	Regulator
V6U69_RS00025 (V6U69_00025)	rlmH	5000..5479 (+)	480	WP_107373293.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
V6U69_RS00030 (V6U69_00030)	-	5496..6179 (+)	684	WP_002892206.1	YoaK family protein	-
V6U69_RS00050 (V6U69_00050)	-	6729..9323 (-)	2595	WP_410533836.1	YfhO family protein	-

Sequence

Protein

• Length: 411 a.a.
• Molecular weight: 42959.14 Da
• Isoelectric Point: 4.6304

>NTDB_id=940753 V6U69_RS00020 WP_002892211.1 3559..4794(-) (htrA) [Streptococcus salivarius strain KSS10]
MKKFNWKKIVAPIAMLVIGLLGGLLGAFILLTAAGVSFTNTTDTGVKTAKTVYNNTTDTTKAVKKVQNAVVSVINYQEGS
SSDSLNELYGRIFGGDDSSDSSQDKSKDSDGLQVAGEGSGVIYKKDGKEAYIVTNNHVVDGAKKLEIMLSDGSKITGELV
GKDTYSDLAVVKVSSDKIKTVAEFADSNSLTVGEKAIAIGSPLGTEYANSVTEGIVSSLSRTVTMQNDNGETVSTNAIQT
DAAINPGNSGGALVNIEGQVIGINSSKISSTSAVAGSAVEGMGFAIPSNDVVEIINQLEKDGKVTRPALGISMADLNSLS
SSATSKLDLPDEVKSGVVVGSVQKGMPADGKLQENDVITEIDGKEISSKTDIQTNLYSHSIGDTIKVTFYRGKEKKTEEL
KLTKSTEDLSD

Nucleotide

• Length: 1236 bp

>NTDB_id=940753 V6U69_RS00020 WP_002892211.1 3559..4794(-) (htrA) [Streptococcus salivarius strain KSS10]
GTGAAAAAATTTAACTGGAAAAAAATAGTAGCGCCAATTGCAATGCTTGTTATTGGCTTACTAGGTGGTCTACTAGGTGC
CTTTATCCTATTAACAGCAGCAGGGGTATCTTTTACCAATACAACAGATACAGGTGTTAAAACAGCTAAGACCGTATACA
ACAATACAACAGATACAACTAAGGCCGTTAAGAAAGTACAAAATGCCGTTGTTTCTGTCATCAATTACCAAGAAGGCTCA
TCTTCAGATTCCCTAAATGAACTTTATGGTCGTATTTTTGGTGGAGATGATAGTTCTGATTCTAGCCAAGACAAATCAAA
AGATTCTGATGGATTGCAAGTCGCTGGTGAAGGTTCCGGTGTTATCTATAAAAAAGATGGGAAAGAGGCCTACATCGTAA
CCAACAACCACGTTGTTGATGGTGCTAAAAAACTTGAAATCATGCTTTCAGATGGATCAAAAATTACTGGTGAACTCGTT
GGTAAAGATACTTACTCTGACCTAGCAGTTGTCAAAGTTTCTTCAGATAAAATAAAAACCGTCGCAGAATTTGCAGATTC
AAACTCCCTCACAGTTGGTGAAAAGGCAATTGCTATCGGTAGCCCACTTGGTACCGAATACGCCAACTCAGTAACAGAGG
GAATCGTATCTAGCCTTAGCCGTACCGTAACTATGCAAAACGACAATGGTGAAACTGTCTCAACAAATGCTATCCAAACA
GATGCTGCCATTAACCCTGGTAACTCTGGTGGTGCCTTAGTCAATATTGAAGGACAAGTTATTGGTATTAACTCAAGTAA
GATTTCATCAACGTCAGCAGTCGCTGGTAGTGCCGTTGAAGGTATGGGATTCGCCATTCCATCAAACGATGTTGTCGAAA
TCATTAATCAATTGGAAAAAGACGGTAAAGTTACACGCCCAGCCCTAGGAATCTCAATGGCCGATCTTAATAGCCTTTCT
AGCAGTGCAACTTCTAAATTAGATTTACCAGATGAAGTTAAATCTGGAGTTGTTGTCGGTAGCGTTCAAAAAGGTATGCC
AGCTGACGGTAAACTTCAAGAAAATGATGTTATTACTGAAATTGACGGTAAGGAAATCAGCTCAAAAACTGATATTCAAA
CCAATCTTTACAGCCATAGTATCGGAGATACAATCAAGGTAACCTTCTATCGTGGTAAAGAGAAGAAAACTGAAGAACTT
AAATTAACAAAATCTACAGAAGACTTATCTGACTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (118-263)

• Peptidase family M50 (Peptidase_M50) (4-406)

• PDZ domain (PDZ_2) (307-402)

3D structure

• AlphaFold DB: J7SI15

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.787	98.054	0.606
htrA	Streptococcus gordonii str. Challis substr. CH1	57.524	100	0.577
htrA	Streptococcus mitis NCTC 12261	54.768	99.513	0.545
htrA	Streptococcus pneumoniae TIGR4	54.523	99.513	0.543
htrA	Streptococcus pneumoniae D39	54.523	99.513	0.543
htrA	Streptococcus pneumoniae Rx1	54.523	99.513	0.543
htrA	Streptococcus pneumoniae R6	54.523	99.513	0.543