Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   V6T26_RS04270 Genome accession   NZ_CP145858
Coordinates   938618..939292 (+) Length   224 a.a.
NCBI ID   WP_002891134.1    Uniprot ID   J7TS49
Organism   Streptococcus salivarius strain KSS11     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 933618..944292
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V6T26_RS04250 (V6T26_04250) - 934734..935306 (-) 573 WP_004182389.1 ECF transporter S component -
  V6T26_RS04255 (V6T26_04255) coaC 935335..935880 (-) 546 WP_410541496.1 phosphopantothenoylcysteine decarboxylase -
  V6T26_RS04260 (V6T26_04260) - 935873..936556 (-) 684 WP_410541497.1 phosphopantothenate--cysteine ligase -
  V6T26_RS04265 (V6T26_04265) - 936750..938420 (+) 1671 WP_247924893.1 formate--tetrahydrofolate ligase -
  V6T26_RS04270 (V6T26_04270) ciaR 938618..939292 (+) 675 WP_002891134.1 response regulator transcription factor Regulator
  V6T26_RS04275 (V6T26_04275) ciaH 939282..940697 (+) 1416 WP_410541498.1 sensor histidine kinase Regulator
  V6T26_RS04280 (V6T26_04280) rpsT 940782..941018 (-) 237 WP_004182129.1 30S ribosomal protein S20 -
  V6T26_RS04285 (V6T26_04285) coaA 941088..942008 (-) 921 WP_013990467.1 type I pantothenate kinase -
  V6T26_RS04290 (V6T26_04290) - 942121..942711 (+) 591 WP_073689922.1 class I SAM-dependent methyltransferase -
  V6T26_RS04295 (V6T26_04295) - 942708..943985 (+) 1278 WP_073689921.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25362.02 Da        Isoelectric Point: 4.2897

>NTDB_id=940245 V6T26_RS04270 WP_002891134.1 938618..939292(+) (ciaR) [Streptococcus salivarius strain KSS11]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=940245 V6T26_RS04270 WP_002891134.1 938618..939292(+) (ciaR) [Streptococcus salivarius strain KSS11]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTAATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae D39

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae R6

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.444

99.554

0.871
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  vicR Streptococcus mutans UA159

35.983

100

0.384
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362