Detailed information NTG0938691

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: LBA42_RS04470
• Genome accession: NZ_CP145437
• Coordinates: 887744..888481 (-)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain HAC 39-1996
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 882744..893481

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LBA42_RS04450 (LBA42_04450)	comA/nlmT	883121..884764 (+)	1644	WP_078133841.1	peptide cleavage/export ABC transporter	Regulator
LBA42_RS04455 (LBA42_04455)	-	884775..886136 (+)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
LBA42_RS04460 (LBA42_04460)	blpC	886193..886348 (+)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
LBA42_RS04465 (LBA42_04465)	-	886390..887730 (-)	1341	WP_001017638.1	sensor histidine kinase	-
LBA42_RS04470 (LBA42_04470)	comE/blpR	887744..888481 (-)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
LBA42_RS04475 (LBA42_04475)	-	888486..888824 (-)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
LBA42_RS04480 (LBA42_04480)	-	889101..889430 (+)	330	WP_000132572.1	hypothetical protein	-
LBA42_RS04485 (LBA42_04485)	-	889598..890647 (-)	1050	WP_000653767.1	ABC transporter permease	-
LBA42_RS04490 (LBA42_04490)	pptA	890644..891375 (-)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
LBA42_RS04495 (LBA42_04495)	-	891443..891853 (+)	411	WP_001278299.1	HIT family protein	-
LBA42_RS04500 (LBA42_04500)	-	891863..892150 (+)	288	WP_000777760.1	hypothetical protein	-
LBA42_RS04505 (LBA42_04505)	-	892312..892551 (+)	240	WP_001810235.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=938691 LBA42_RS04470 WP_001219120.1 887744..888481(-) (comE/blpR) [Streptococcus pneumoniae strain HAC 39-1996]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=938691 LBA42_RS04470 WP_001219120.1 887744..888481(-) (comE/blpR) [Streptococcus pneumoniae strain HAC 39-1996]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363