Detailed information NTG0925402

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: VKP34_RS00330
• Genome accession: NZ_CP142358
• Coordinates: 53367..54278 (+)
• Length: 303 a.a.
• NCBI ID: WP_136112109.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 6702-99
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48367..59278

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP34_RS00310 (VKP34_00310)	purE	48660..49151 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
VKP34_RS00315 (VKP34_00315)	purK	49138..50211 (+)	1074	WP_326658205.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
VKP34_RS00320 (VKP34_00320)	-	50232..51572 (+)	1341	WP_002986685.1	hypothetical protein	-
VKP34_RS00325 (VKP34_00325)	purB	51941..53233 (+)	1293	WP_030127024.1	adenylosuccinate lyase	-
VKP34_RS00330 (VKP34_00330)	comR	53367..54278 (+)	912	WP_136112109.1	helix-turn-helix domain-containing protein	Regulator
VKP34_RS00335 (VKP34_00335)	comS	54369..54467 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
VKP34_RS00340 (VKP34_00340)	ruvB	54498..55496 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
VKP34_RS00345 (VKP34_00345)	-	55634..56071 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
VKP34_RS00350 (VKP34_00350)	-	56094..56495 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
VKP34_RS00355 (VKP34_00355)	-	56492..58267 (+)	1776	WP_002994672.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35924.69 Da
• Isoelectric Point: 5.1460

>NTDB_id=925402 VKP34_RS00330 WP_136112109.1 53367..54278(+) (comR) [Streptococcus pyogenes strain 6702-99]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLKLPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=925402 VKP34_RS00330 WP_136112109.1 53367..54278(+) (comR) [Streptococcus pyogenes strain 6702-99]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAAAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.01	100	0.99
comR	Streptococcus pyogenes MGAS8232	58.14	99.34	0.578
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.102	97.36	0.449
comR	Streptococcus suis P1/7	37.5	97.69	0.366
comR	Streptococcus suis 05ZYH33	37.5	97.69	0.366