Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   VKP36_RS02240 Genome accession   NZ_CP142357
Coordinates   422763..423473 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain AW-534     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 417763..428473
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP36_RS02220 (VKP36_02220) - 417965..418750 (+) 786 WP_326625166.1 ABC transporter permease -
  VKP36_RS02225 (VKP36_02225) - 419159..420307 (+) 1149 WP_136083567.1 acetyl-CoA C-acyltransferase -
  VKP36_RS02230 (VKP36_02230) - 420264..421511 (+) 1248 WP_326625168.1 AMP-binding protein -
  VKP36_RS02235 (VKP36_02235) - 421567..422601 (+) 1035 WP_011284595.1 DUF3114 domain-containing protein -
  VKP36_RS02240 (VKP36_02240) vicR 422763..423473 (+) 711 WP_002985645.1 response regulator YycF Regulator
  VKP36_RS02245 (VKP36_02245) vicK 423466..424818 (+) 1353 WP_002990673.1 cell wall metabolism sensor histidine kinase VicK Regulator
  VKP36_RS02250 (VKP36_02250) vicX 424822..425631 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  VKP36_RS02255 (VKP36_02255) rnc 426074..426766 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=925372 VKP36_RS02240 WP_002985645.1 422763..423473(+) (vicR) [Streptococcus pyogenes strain AW-534]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=925372 VKP36_RS02240 WP_002985645.1 422763..423473(+) (vicR) [Streptococcus pyogenes strain AW-534]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAGCACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364