Detailed information NTG0925244

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: VKP40_RS00330
• Genome accession: NZ_CP142355
• Coordinates: 53356..54267 (+)
• Length: 303 a.a.
• NCBI ID: WP_326675816.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain A946
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48356..59267

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP40_RS00310 (VKP40_00310)	purE	48651..49142 (+)	492	WP_032464131.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
VKP40_RS00315 (VKP40_00315)	purK	49129..50202 (+)	1074	WP_326675812.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
VKP40_RS00320 (VKP40_00320)	-	50223..51563 (+)	1341	WP_326675814.1	hypothetical protein	-
VKP40_RS00325 (VKP40_00325)	purB	51932..53224 (+)	1293	WP_111686141.1	adenylosuccinate lyase	-
VKP40_RS00330 (VKP40_00330)	comR	53356..54267 (+)	912	WP_326675816.1	helix-turn-helix domain-containing protein	Regulator
VKP40_RS00335 (VKP40_00335)	comS	54358..54456 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
VKP40_RS00340 (VKP40_00340)	ruvB	54487..55485 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
VKP40_RS00345 (VKP40_00345)	-	55623..56060 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
VKP40_RS00350 (VKP40_00350)	-	56083..56484 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
VKP40_RS00355 (VKP40_00355)	-	56481..58256 (+)	1776	WP_136108488.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35790.47 Da
• Isoelectric Point: 5.1404

>NTDB_id=925244 VKP40_RS00330 WP_326675816.1 53356..54267(+) (comR) [Streptococcus pyogenes strain A946]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREGQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMHEWKLSIFYLKDISRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=925244 VKP40_RS00330 WP_326675816.1 53356..54267(+) (comR) [Streptococcus pyogenes strain A946]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGGGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGCATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAG
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	98.68	100	0.987
comR	Streptococcus pyogenes MGAS8232	58.14	99.34	0.578
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366