Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   VOI49_RS05580 Genome accession   NZ_CP142018
Coordinates   1093301..1093975 (-) Length   224 a.a.
NCBI ID   WP_003050941.1    Uniprot ID   A0A380JVA5
Organism   Streptococcus dysgalactiae strain lu24     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1088301..1098975
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VOI49_RS05555 - 1088486..1089763 (-) 1278 WP_003050932.1 pyrimidine-nucleoside phosphorylase -
  VOI49_RS05560 - 1089750..1090349 (-) 600 WP_037584951.1 class I SAM-dependent methyltransferase -
  VOI49_RS05565 coaA 1090618..1091538 (+) 921 WP_003050936.1 type I pantothenate kinase -
  VOI49_RS05570 rpsT 1091592..1091840 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  VOI49_RS05575 ciaH 1091998..1093308 (-) 1311 WP_115252901.1 sensor histidine kinase Regulator
  VOI49_RS05580 ciaR 1093301..1093975 (-) 675 WP_003050941.1 response regulator transcription factor Regulator
  VOI49_RS05585 - 1094180..1096717 (-) 2538 WP_003050944.1 M1 family metallopeptidase -
  VOI49_RS05590 phoU 1096917..1097570 (-) 654 WP_003050946.1 phosphate signaling complex protein PhoU -
  VOI49_RS05595 pstB 1097648..1098406 (-) 759 WP_003050947.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25539.54 Da        Isoelectric Point: 4.4684

>NTDB_id=921023 VOI49_RS05580 WP_003050941.1 1093301..1093975(-) (ciaR) [Streptococcus dysgalactiae strain lu24]
MLKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGKKEVQVDGQPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDLVDKLQTLRSVGYILKSHE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=921023 VOI49_RS05580 WP_003050941.1 1093301..1093975(-) (ciaR) [Streptococcus dysgalactiae strain lu24]
ATGCTCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGAGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGTTTTCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCAGTGTTGATCATGACAGCC
AAAGAAAGCCTAGATGATAAGGGACATGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACGGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAACGTCGTAG
TGGATTTAGGAAAAAAAGAAGTTCAAGTGGATGGCCAACCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTTTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATCTTGTGGACAAACTTCAGACATTAA
GAAGTGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380JVA5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

83.71

98.661

0.826
  ciaR Streptococcus pneumoniae D39

83.71

98.661

0.826
  ciaR Streptococcus pneumoniae R6

83.71

98.661

0.826
  ciaR Streptococcus pneumoniae TIGR4

83.71

98.661

0.826
  ciaR Streptococcus mutans UA159

83.258

98.661

0.821
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.778

100

0.379
  vicR Streptococcus mutans UA159

35.443

100

0.375