Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   VNN37_RS04670 Genome accession   NZ_CP141707
Coordinates   916206..917423 (-) Length   405 a.a.
NCBI ID   WP_003133516.1    Uniprot ID   A0A3D4RHV6
Organism   Lactococcus garvieae strain M21102102     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 911206..922423
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VNN37_RS04645 (VNN37_04645) - 911505..912254 (+) 750 WP_019298937.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  VNN37_RS04650 (VNN37_04650) - 912413..913462 (+) 1050 WP_339000789.1 BMP family protein -
  VNN37_RS04655 (VNN37_04655) - 913488..913712 (-) 225 WP_003133519.1 DUF1797 family protein -
  VNN37_RS04660 (VNN37_04660) - 913763..915097 (-) 1335 WP_339000791.1 glycosyltransferase family 4 protein -
  VNN37_RS04665 (VNN37_04665) - 915110..916108 (-) 999 WP_339000793.1 glycosyltransferase family 4 protein -
  VNN37_RS04670 (VNN37_04670) htrA 916206..917423 (-) 1218 WP_003133516.1 trypsin-like peptidase domain-containing protein Regulator
  VNN37_RS04675 (VNN37_04675) rlmH 917727..918206 (+) 480 WP_003133515.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  VNN37_RS04680 (VNN37_04680) - 918203..918850 (+) 648 WP_042219626.1 DNA alkylation repair protein -
  VNN37_RS04685 (VNN37_04685) yajC 918925..919260 (+) 336 WP_014025468.1 preprotein translocase subunit YajC -
  VNN37_RS04690 (VNN37_04690) - 919461..920198 (+) 738 WP_003133511.1 isoprenyl transferase -
  VNN37_RS04695 (VNN37_04695) - 920195..920989 (+) 795 WP_003133509.1 phosphatidate cytidylyltransferase -
  VNN37_RS04700 (VNN37_04700) eeP 921165..922412 (+) 1248 WP_014025467.1 RIP metalloprotease RseP Regulator

Sequence

Protein


Download         Length: 405 a.a.        Molecular weight: 41787.63 Da        Isoelectric Point: 4.8808

>NTDB_id=918634 VNN37_RS04670 WP_003133516.1 916206..917423(-) (htrA) [Lactococcus garvieae strain M21102102]
MAKKNIASLLITGVAGGAIALGGSAIYQNMTNTPSSNNTSDNSVSTVNVQVNTDTTKAIKKISNTVVSVLNYQKSSSSND
FEKIFGGGDTSSNDSNTPQLAGEGSGVIYKKDGNTAYIVTNYHVIEGASSLEVLMAGGQKVTAEVVGSDAYSDLAVLKID
AKYVKETATFGNSDKLTVGEPAIAVGSPLGSEYANSATEGIVSSLNRNVTLQNSQGQTINVNAIQTDAAINPGNSGGALI
NIQGQVIGITSSKITSTPSGTSGSGVSVEGMGFAIPANDVVNIINKLEKDGKVIRPALGVQMVNLSSLSQNMLASLNLPE
NVTNGVAIAEVQSGMPAAKAGLKQGDVIVKINDDEITSSVNLQSTLYKSSIGDTIKVTYYRDGKQATANIKLDKTSSDIN
FDKQN

Nucleotide


Download         Length: 1218 bp        

>NTDB_id=918634 VNN37_RS04670 WP_003133516.1 916206..917423(-) (htrA) [Lactococcus garvieae strain M21102102]
ATGGCAAAGAAAAATATCGCCTCATTACTTATTACGGGCGTAGCCGGAGGTGCTATCGCTCTTGGAGGTAGTGCTATCTA
CCAAAACATGACCAATACACCATCATCTAATAACACTTCGGACAATTCTGTAAGTACGGTTAACGTCCAAGTCAATACAG
ATACCACCAAAGCAATCAAGAAAATTTCGAACACTGTTGTTTCCGTTCTTAATTACCAAAAATCGTCCTCAAGCAACGAT
TTTGAGAAGATTTTCGGTGGAGGCGATACAAGCAGCAATGACAGTAACACGCCACAGCTGGCTGGTGAAGGTTCTGGTGT
TATTTATAAAAAAGATGGCAATACAGCATACATCGTCACCAACTATCACGTGATTGAAGGTGCTTCTTCCTTAGAAGTTC
TCATGGCTGGCGGCCAAAAAGTTACTGCTGAAGTTGTTGGTTCTGATGCTTATTCTGATTTAGCTGTCCTCAAAATTGAT
GCTAAGTATGTCAAAGAAACAGCAACATTCGGTAACTCTGACAAACTTACTGTTGGTGAGCCCGCTATCGCGGTTGGTTC
TCCTCTTGGAAGTGAGTATGCCAACTCAGCAACGGAAGGGATTGTTTCAAGTCTTAATCGTAATGTTACGCTGCAAAACA
GCCAAGGCCAAACAATTAATGTGAACGCAATTCAAACCGATGCAGCAATTAACCCAGGTAACTCTGGTGGTGCACTCATA
AATATTCAGGGACAAGTCATCGGGATTACTTCAAGTAAAATTACCTCAACACCAAGCGGAACAAGCGGCAGTGGTGTCTC
TGTAGAAGGAATGGGCTTTGCGATACCAGCCAATGATGTGGTCAATATTATCAATAAGTTGGAAAAAGATGGCAAAGTTA
TTCGACCTGCTCTCGGTGTACAAATGGTCAACTTGTCAAGTCTTTCACAAAATATGTTGGCTTCACTTAATCTTCCTGAA
AATGTGACAAATGGTGTTGCTATCGCTGAAGTTCAATCAGGAATGCCTGCTGCCAAAGCTGGACTCAAGCAAGGTGACGT
TATTGTCAAAATCAATGATGACGAAATCACTTCAAGTGTGAACCTTCAAAGTACACTTTATAAGTCATCGATTGGTGATA
CGATTAAGGTAACTTATTATCGTGACGGAAAACAAGCTACTGCGAATATCAAGTTAGATAAGACAAGTAGTGACATCAAC
TTTGACAAACAAAATTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(294-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3D4RHV6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

53.634

98.519

0.528
  htrA Streptococcus pneumoniae Rx1

53.383

98.519

0.526
  htrA Streptococcus pneumoniae D39

53.383

98.519

0.526
  htrA Streptococcus pneumoniae R6

53.383

98.519

0.526
  htrA Streptococcus pneumoniae TIGR4

53.383

98.519

0.526
  htrA Streptococcus mutans UA159

56.085

93.333

0.523
  htrA Streptococcus gordonii str. Challis substr. CH1

54.22

96.543

0.523