Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   U0450_RS10315 Genome accession   NZ_CP139863
Coordinates   1993155..1993859 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 15P2112     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1988155..1998859
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0450_RS10295 coaC 1988445..1988996 (-) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -
  U0450_RS10300 coaB 1989008..1989697 (-) 690 WP_000699503.1 phosphopantothenate--cysteine ligase -
  U0450_RS10305 - 1989927..1991597 (+) 1671 WP_050102479.1 formate--tetrahydrofolate ligase -
  U0450_RS10310 mutY 1991925..1993100 (+) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  U0450_RS10315 micA 1993155..1993859 (+) 705 WP_000722076.1 response regulator YycF Regulator
  U0450_RS10320 micB 1993852..1995201 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  U0450_RS10325 vicX 1995203..1996012 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  U0450_RS10330 relB 1996103..1996345 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  U0450_RS10335 - 1996347..1996601 (+) 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin -
  U0450_RS10340 - 1996648..1997421 (+) 774 WP_000725951.1 potassium channel family protein -
  U0450_RS10345 - 1997684..1998670 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=911606 U0450_RS10315 WP_000722076.1 1993155..1993859(+) (micA) [Streptococcus pneumoniae strain 15P2112]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=911606 U0450_RS10315 WP_000722076.1 1993155..1993859(+) (micA) [Streptococcus pneumoniae strain 15P2112]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38