Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   U0450_RS05275 Genome accession   NZ_CP139863
Coordinates   1051011..1052192 (-) Length   393 a.a.
NCBI ID   WP_000681598.1    Uniprot ID   A0A0B7M448
Organism   Streptococcus pneumoniae strain 15P2112     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1046011..1057192
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0450_RS05255 - 1047067..1047261 (-) 195 WP_000285194.1 DUF951 domain-containing protein -
  U0450_RS05260 dnaN 1047326..1048462 (-) 1137 WP_000581157.1 DNA polymerase III subunit beta -
  U0450_RS05265 dnaA 1048621..1049982 (-) 1362 WP_000660618.1 chromosomal replication initiator protein DnaA -
  U0450_RS05270 spo0J 1050195..1050953 (-) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator
  U0450_RS05275 htrA 1051011..1052192 (-) 1182 WP_000681598.1 S1C family serine protease Regulator
  U0450_RS05280 rlmH 1052375..1052854 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  U0450_RS05290 comC/comC1 1053136..1053261 (+) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  U0450_RS05295 comD/comD1 1053282..1054607 (+) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  U0450_RS05300 comE 1054604..1055356 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  U0450_RS05315 - 1055599..1056141 (-) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41827.69 Da        Isoelectric Point: 6.8902

>NTDB_id=911557 U0450_RS05275 WP_000681598.1 1051011..1052192(-) (htrA) [Streptococcus pneumoniae strain 15P2112]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=911557 U0450_RS05275 WP_000681598.1 1051011..1052192(-) (htrA) [Streptococcus pneumoniae strain 15P2112]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M448

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.746

100

0.997
  htrA Streptococcus pneumoniae D39

99.746

100

0.997
  htrA Streptococcus pneumoniae R6

99.746

100

0.997
  htrA Streptococcus pneumoniae TIGR4

99.746

100

0.997
  htrA Streptococcus mitis NCTC 12261

97.455

100

0.975
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.672
  htrA Streptococcus mutans UA159

54.822

100

0.55