Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   U0449_RS02825 Genome accession   NZ_CP139862
Coordinates   559682..560419 (-) Length   245 a.a.
NCBI ID   WP_001219120.1    Uniprot ID   Q9S1I6
Organism   Streptococcus pneumoniae strain 05H0020-2     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 554682..565419
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0449_RS02805 comA/nlmT 555057..556700 (+) 1644 WP_078136507.1 peptide cleavage/export ABC transporter Regulator
  U0449_RS02810 - 556711..558072 (+) 1362 WP_001069075.1 bacteriocin secretion accessory protein -
  U0449_RS02815 blpC 558129..558257 (+) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  U0449_RS02820 - 558328..559668 (-) 1341 WP_001017646.1 sensor histidine kinase -
  U0449_RS02825 comE/blpR 559682..560419 (-) 738 WP_001219120.1 LytTR family DNA-binding domain-containing protein Regulator
  U0449_RS02830 - 560433..560762 (-) 330 WP_050218846.1 LytTR family DNA-binding domain-containing protein -
  U0449_RS02835 - 561039..561368 (+) 330 WP_000132572.1 hypothetical protein -
  U0449_RS02840 - 561536..562585 (-) 1050 WP_001866896.1 ABC transporter permease -
  U0449_RS02845 pptA 562582..563313 (-) 732 WP_001866897.1 ABC transporter ATP-binding protein Regulator
  U0449_RS02850 - 563381..563791 (+) 411 WP_001278301.1 HIT family protein -
  U0449_RS02855 - 563801..564088 (+) 288 WP_000777760.1 hypothetical protein -
  U0449_RS02860 - 564250..564498 (+) 249 WP_138027179.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28754.98 Da        Isoelectric Point: 6.5884

>NTDB_id=911467 U0449_RS02825 WP_001219120.1 559682..560419(-) (comE/blpR) [Streptococcus pneumoniae strain 05H0020-2]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=911467 U0449_RS02825 WP_001219120.1 559682..560419(-) (comE/blpR) [Streptococcus pneumoniae strain 05H0020-2]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363