Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   U0447_RS00570 Genome accession   NZ_CP139861
Coordinates   106318..107022 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 16H2017-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 101318..112022
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0447_RS00540 - 101499..102485 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  U0447_RS00545 - 102786..103529 (-) 744 Protein_105 potassium channel family protein -
  U0447_RS00550 - 103576..103830 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  U0447_RS00555 relB 103832..104074 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  U0447_RS00560 vicX 104165..104974 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  U0447_RS00565 micB 104976..106325 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  U0447_RS00570 micA 106318..107022 (-) 705 WP_000722076.1 response regulator YycF Regulator
  U0447_RS00575 mutY 107078..108253 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  U0447_RS00580 - 108350..108475 (+) 126 WP_001818232.1 hypothetical protein -
  U0447_RS00585 - 108581..110251 (-) 1671 WP_000845295.1 formate--tetrahydrofolate ligase -
  U0447_RS00590 coaB 110481..111170 (+) 690 WP_050232517.1 phosphopantothenate--cysteine ligase -
  U0447_RS00595 coaC 111182..111733 (+) 552 WP_041171335.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=911379 U0447_RS00570 WP_000722076.1 106318..107022(-) (micA) [Streptococcus pneumoniae strain 16H2017-2]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=911379 U0447_RS00570 WP_000722076.1 106318..107022(-) (micA) [Streptococcus pneumoniae strain 16H2017-2]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCACTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38