Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   U0448_RS09950 Genome accession   NZ_CP139860
Coordinates   1952448..1953152 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 21011     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1947448..1958152
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0448_RS09925 coaC 1947738..1948289 (-) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -
  U0448_RS09930 coaB 1948301..1948990 (-) 690 WP_000699503.1 phosphopantothenate--cysteine ligase -
  U0448_RS09935 - 1949220..1950890 (+) 1671 WP_081570900.1 formate--tetrahydrofolate ligase -
  U0448_RS09940 - 1950996..1951121 (-) 126 WP_001818232.1 hypothetical protein -
  U0448_RS09945 mutY 1951218..1952393 (+) 1176 WP_081570899.1 A/G-specific adenine glycosylase -
  U0448_RS09950 micA 1952448..1953152 (+) 705 WP_000722076.1 response regulator YycF Regulator
  U0448_RS09955 micB 1953145..1954494 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  U0448_RS09960 vicX 1954496..1955305 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  U0448_RS09965 relB 1955396..1955638 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  U0448_RS09970 - 1955640..1955894 (+) 255 WP_050221040.1 type II toxin-antitoxin system RelE/ParE family toxin -
  U0448_RS09975 - 1955941..1956714 (+) 774 WP_000731132.1 ion transporter -
  U0448_RS09980 - 1956974..1957960 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=911374 U0448_RS09950 WP_000722076.1 1952448..1953152(+) (micA) [Streptococcus pneumoniae strain 21011]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=911374 U0448_RS09950 WP_000722076.1 1952448..1953152(+) (micA) [Streptococcus pneumoniae strain 21011]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTTTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38