Detailed information NTG0911366

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: U0448_RS07745
• Genome accession: NZ_CP139860
• Coordinates: 1510884..1511471 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 21011
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1505884..1516471

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0448_RS07720	-	1506344..1507684 (+)	1341	WP_050258907.1	sensor histidine kinase	-
U0448_RS07725	blpC	1507712..1507885 (-)	174	WP_050258908.1	quorum-sensing system pheromone BlpC	-
U0448_RS07730	-	1507942..1509303 (-)	1362	WP_042516064.1	bacteriocin secretion accessory protein	-
U0448_RS07735	comA/nlmT	1509314..1509961 (-)	648	WP_078102557.1	ATP-binding cassette domain-containing protein	Regulator
U0448_RS07740	comA/nlmT	1509977..1510990 (-)	1014	WP_307772067.1	ABC transporter transmembrane domain-containing protein	Regulator
U0448_RS07745	comA/nlmT	1510884..1511471 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
U0448_RS07750	blpI	1511753..1511950 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
U0448_RS07755	blpJ	1512417..1512686 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
U0448_RS07760	blpU	1512755..1512985 (+)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
U0448_RS07765	-	1512988..1513107 (+)	120	WP_050079265.1	PncF family bacteriocin immunity protein	-
U0448_RS07770	-	1513893..1514276 (+)	384	WP_000877381.1	hypothetical protein	-
U0448_RS07775	-	1514328..1515017 (+)	690	WP_050258910.1	CPBP family intramembrane glutamic endopeptidase	-
U0448_RS07780	blpZ	1515059..1515292 (+)	234	WP_000276498.1	immunity protein BlpZ	-
U0448_RS07785	-	1515443..1516054 (+)	612	WP_000394036.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=911366 U0448_RS07745 WP_000205166.1 1510884..1511471(-) (comA/nlmT) [Streptococcus pneumoniae strain 21011]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=911366 U0448_RS07745 WP_000205166.1 1510884..1511471(-) (comA/nlmT) [Streptococcus pneumoniae strain 21011]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497