Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SM123_RS06780 Genome accession   NZ_CP139419
Coordinates   1413027..1413707 (-) Length   226 a.a.
NCBI ID   WP_021152983.1    Uniprot ID   -
Organism   Streptococcus lingualis strain S5     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1384745..1417752 1413027..1413707 within 0


Gene organization within MGE regions


Location: 1384745..1417752
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM123_RS06630 (SM123_06630) - 1384745..1385176 (-) 432 WP_320909282.1 hypothetical protein -
  SM123_RS06635 (SM123_06635) - 1385315..1385755 (-) 441 WP_320909283.1 hypothetical protein -
  SM123_RS06640 (SM123_06640) - 1385929..1386396 (-) 468 WP_129824413.1 deaminase -
  SM123_RS06645 (SM123_06645) rplT 1386649..1387008 (-) 360 WP_000124830.1 50S ribosomal protein L20 -
  SM123_RS06650 (SM123_06650) rpmI 1387058..1387258 (-) 201 WP_001125942.1 50S ribosomal protein L35 -
  SM123_RS06655 (SM123_06655) infC 1387292..1387822 (-) 531 WP_003003721.1 translation initiation factor IF-3 -
  SM123_RS06660 (SM123_06660) cmk 1387991..1388671 (-) 681 WP_031574170.1 (d)CMP kinase -
  SM123_RS06665 (SM123_06665) - 1388686..1389141 (-) 456 WP_320909284.1 SAG1386/EF1546 family surface-associated protein -
  SM123_RS06670 (SM123_06670) - 1389187..1389387 (+) 201 WP_320909285.1 ferredoxin -
  SM123_RS06675 (SM123_06675) - 1389397..1389873 (-) 477 WP_023917814.1 EbsA family protein -
  SM123_RS06680 (SM123_06680) - 1389968..1392493 (-) 2526 WP_320909286.1 LTA synthase family protein -
  SM123_RS06685 (SM123_06685) - 1392516..1394003 (-) 1488 WP_320909287.1 DUF2142 domain-containing protein -
  SM123_RS06690 (SM123_06690) - 1394014..1395759 (-) 1746 WP_320909288.1 rhamnan synthesis F family protein -
  SM123_RS06695 (SM123_06695) - 1395761..1397110 (-) 1350 WP_320909289.1 glycosyltransferase -
  SM123_RS06700 (SM123_06700) - 1397123..1398346 (-) 1224 WP_023026986.1 ABC transporter ATP-binding protein -
  SM123_RS06705 (SM123_06705) - 1398346..1399152 (-) 807 WP_214259797.1 ABC transporter permease -
  SM123_RS06710 (SM123_06710) - 1399155..1400093 (-) 939 WP_320909290.1 glycosyltransferase family 2 protein -
  SM123_RS06715 (SM123_06715) cps2T 1400090..1401238 (-) 1149 WP_320909291.1 beta 1-4 rhamnosyltransferase Cps2T -
  SM123_RS06720 (SM123_06720) rfbD 1401345..1402196 (-) 852 WP_320909292.1 dTDP-4-dehydrorhamnose reductase -
  SM123_RS06725 (SM123_06725) - 1402262..1403188 (-) 927 WP_320909293.1 glycosyltransferase family 2 protein -
  SM123_RS06730 (SM123_06730) - 1403245..1404219 (-) 975 WP_320909294.1 glycosyltransferase family 2 protein -
  SM123_RS06735 (SM123_06735) - 1404318..1405100 (-) 783 WP_320909295.1 glycosyltransferase family 2 protein -
  SM123_RS06740 (SM123_06740) - 1405084..1406361 (-) 1278 WP_320909296.1 lipopolysaccharide biosynthesis protein -
  SM123_RS06745 (SM123_06745) - 1406351..1406686 (-) 336 WP_049472006.1 DUF2304 domain-containing protein -
  SM123_RS06750 (SM123_06750) - 1406688..1407398 (-) 711 WP_049472007.1 glycosyltransferase family 2 protein -
  SM123_RS06755 (SM123_06755) - 1407526..1408506 (+) 981 WP_201037161.1 Gfo/Idh/MocA family protein -
  SM123_RS06760 (SM123_06760) - 1408503..1409588 (+) 1086 WP_320909297.1 DEAD/DEAH box helicase -
  SM123_RS06765 (SM123_06765) - 1409631..1411013 (-) 1383 WP_320909298.1 polysaccharide deacetylase family protein -
  SM123_RS06770 (SM123_06770) - 1411272..1411652 (-) 381 WP_023917784.1 VOC family protein -
  SM123_RS06775 (SM123_06775) ciaH 1411685..1413043 (-) 1359 WP_320909299.1 HAMP domain-containing sensor histidine kinase Regulator
  SM123_RS06780 (SM123_06780) ciaR 1413027..1413707 (-) 681 WP_021152983.1 response regulator transcription factor Regulator
  SM123_RS06785 (SM123_06785) - 1413843..1414364 (-) 522 WP_320909300.1 hypothetical protein -
  SM123_RS06790 (SM123_06790) - 1414570..1415103 (+) 534 WP_320909301.1 biotin transporter BioY -
  SM123_RS06795 (SM123_06795) - 1415256..1415978 (-) 723 WP_320909302.1 ABC transporter permease -
  SM123_RS06800 (SM123_06800) - 1415980..1416935 (-) 956 Protein_1321 ABC transporter ATP-binding protein -
  SM123_RS06805 (SM123_06805) - 1417042..1417752 (+) 711 WP_070660283.1 LytTR family DNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25736.45 Da        Isoelectric Point: 4.3559

>NTDB_id=909536 SM123_RS06780 WP_021152983.1 1413027..1413707(-) (ciaR) [Streptococcus lingualis strain S5]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGIYDLILLDLMLPEKDGFHVLKELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLNYGNLKVNLSTNSTYVDGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVENLQTLRSVGYILKDANQN

Nucleotide


Download         Length: 681 bp        

>NTDB_id=909536 SM123_RS06780 WP_021152983.1 1413027..1413707(-) (ciaR) [Streptococcus lingualis strain S5]
ATGATTAAAATTCTATTGGTCGAAGATGACCTTGGTTTATCAAATTCAGTATTTGATTTTTTAGATGATTTTGCGGACGT
TATGCAGGTCTTTGACGGAGAAGAAGGTCTTTACGAAGCAGAAAGCGGGATCTATGATTTGATTCTGCTGGATCTCATGC
TTCCTGAAAAAGACGGCTTCCATGTTCTAAAAGAGTTGCGTGAAAAAGGCGTGACAACCCCTGTTTTGATCATGACAGCT
AAAGAAAGTCTGGATGACAAAGGGCACGGCTTTGAGCTAGGTGCAGACGATTACCTCACCAAACCTTTCTACCTAGAAGA
ACTCAAGATGCGGATTCAAGCCCTCTTGAAGCGCTCAGGAAAGGTCAATGAAAACACCCTTAATTATGGCAATTTGAAGG
TCAATTTATCTACCAATTCGACTTATGTGGATGGGAAAGAAGTGGAACTTCTTGGGAAGGAATTTGATCTTTTGGTCTAT
TTCCTTCAAAACCAAAATGTCATCCTTCCAAAGACCCAGATCTTCGATCGTCTCTGGGGCTTTGATAGTGACACAACCAT
CTCAGTGGTTGAAGTCTATGTTTCAAAAATCCGTAAGAAATTAAAAGGTACTGATTTCGTTGAGAACTTGCAAACATTGC
GCAGTGTGGGGTATATCTTAAAAGATGCTAACCAGAATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae D39

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae R6

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae TIGR4

90.625

99.115

0.898
  ciaR Streptococcus mutans UA159

88.839

99.115

0.881
  vicR Streptococcus mutans UA159

36.481

100

0.376
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.445

100

0.376
  covR Streptococcus salivarius strain HSISS4

36.123

100

0.363