Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4701_RS02625 Genome accession   NZ_CP137114
Coordinates   523575..524312 (-) Length   245 a.a.
NCBI ID   WP_001219121.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 15P3054     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 518575..529312
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4701_RS02600 comA/nlmT 518967..519773 (+) 807 WP_317805977.1 ABC transporter transmembrane domain-containing protein Regulator
  R4701_RS02605 comA/nlmT 519810..520592 (+) 783 WP_317805978.1 ATP-binding cassette domain-containing protein Regulator
  R4701_RS02610 - 520603..521964 (+) 1362 WP_001069085.1 bacteriocin secretion accessory protein -
  R4701_RS02615 blpC 522021..522176 (+) 156 WP_000358810.1 quorum-sensing system pheromone BlpC -
  R4701_RS02620 - 522221..523561 (-) 1341 WP_317805979.1 sensor histidine kinase -
  R4701_RS02625 comE/blpR 523575..524312 (-) 738 WP_001219121.1 response regulator transcription factor Regulator
  R4701_RS02630 - 524317..524655 (-) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  R4701_RS02635 - 524931..525260 (+) 330 WP_000132572.1 hypothetical protein -
  R4701_RS02640 - 525428..526477 (-) 1050 WP_000653766.1 ABC transporter permease -
  R4701_RS02645 pptA 526474..527205 (-) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  R4701_RS02650 - 527273..527683 (+) 411 WP_001278301.1 HIT family protein -
  R4701_RS02655 - 527693..527980 (+) 288 WP_000777760.1 hypothetical protein -
  R4701_RS02660 - 528142..528381 (+) 240 WP_001812223.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28740.91 Da        Isoelectric Point: 6.4140

>NTDB_id=896159 R4701_RS02625 WP_001219121.1 523575..524312(-) (comE/blpR) [Streptococcus pneumoniae strain 15P3054]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=896159 R4701_RS02625 WP_001219121.1 523575..524312(-) (comE/blpR) [Streptococcus pneumoniae strain 15P3054]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCTCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTTTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38