Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4707_RS00520 Genome accession   NZ_CP137113
Coordinates   100813..101517 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain ZGX     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 95813..106517
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4707_RS00490 - 96018..97004 (+) 987 WP_081542829.1 L-lactate dehydrogenase -
  R4707_RS00495 - 97281..98024 (-) 744 Protein_98 potassium channel family protein -
  R4707_RS00500 - 98071..98325 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4707_RS00505 relB 98327..98569 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R4707_RS00510 vicX 98660..99469 (-) 810 WP_050103757.1 MBL fold metallo-hydrolase Regulator
  R4707_RS00515 micB 99471..100820 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4707_RS00520 micA 100813..101517 (-) 705 WP_000722076.1 response regulator YycF Regulator
  R4707_RS00525 mutY 101573..102748 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  R4707_RS00530 - 103077..104747 (-) 1671 WP_000845287.1 formate--tetrahydrofolate ligase -
  R4707_RS00535 coaB 104977..105666 (+) 690 WP_000699488.1 phosphopantothenate--cysteine ligase -
  R4707_RS00540 coaC 105678..106229 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=896067 R4707_RS00520 WP_000722076.1 100813..101517(-) (micA) [Streptococcus pneumoniae strain ZGX]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=896067 R4707_RS00520 WP_000722076.1 100813..101517(-) (micA) [Streptococcus pneumoniae strain ZGX]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTATGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38