Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4700_RS00455 Genome accession   NZ_CP137112
Coordinates   87721..88425 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 02H2025     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 82721..93425
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4700_RS00425 - 83034..84020 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  R4700_RS00430 - 84280..84932 (-) 653 Protein_85 potassium channel family protein -
  R4700_RS00435 - 84979..85233 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4700_RS00440 relB 85235..85477 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R4700_RS00445 vicX 85568..86377 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4700_RS00450 micB 86379..87728 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4700_RS00455 micA 87721..88425 (-) 705 WP_000722076.1 response regulator YycF Regulator
  R4700_RS00460 mutY 88480..89655 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  R4700_RS00465 - 89752..89877 (+) 126 WP_001818232.1 hypothetical protein -
  R4700_RS00470 - 89983..91653 (-) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  R4700_RS00475 coaB 91883..92572 (+) 690 WP_061652912.1 phosphopantothenate--cysteine ligase -
  R4700_RS00480 coaC 92584..93135 (+) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=895995 R4700_RS00455 WP_000722076.1 87721..88425(-) (micA) [Streptococcus pneumoniae strain 02H2025]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=895995 R4700_RS00455 WP_000722076.1 87721..88425(-) (micA) [Streptococcus pneumoniae strain 02H2025]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38