Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4712_RS02875 Genome accession   NZ_CP137110
Coordinates   576676..577413 (-) Length   245 a.a.
NCBI ID   WP_001219120.1    Uniprot ID   Q9S1I6
Organism   Streptococcus pneumoniae strain 16H2041     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 571676..582413
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4712_RS02855 comA/nlmT 572051..573616 (+) 1566 WP_308410653.1 peptide cleavage/export ABC transporter Regulator
  R4712_RS02860 - 573705..575066 (+) 1362 WP_001069060.1 bacteriocin secretion accessory protein -
  R4712_RS02865 blpC 575123..575251 (+) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  R4712_RS02870 - 575322..576662 (-) 1341 WP_001017642.1 sensor histidine kinase -
  R4712_RS02875 comE/blpR 576676..577413 (-) 738 WP_001219120.1 LytTR family DNA-binding domain-containing protein Regulator
  R4712_RS02880 - 577418..577756 (-) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  R4712_RS02885 - 578032..578361 (+) 330 WP_000132572.1 hypothetical protein -
  R4712_RS02890 - 578529..579578 (-) 1050 WP_000653771.1 ABC transporter permease -
  R4712_RS02895 pptA 579575..580306 (-) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  R4712_RS02900 - 580374..580784 (+) 411 WP_044791647.1 HIT family protein -
  R4712_RS02905 - 580794..581081 (+) 288 WP_000777753.1 hypothetical protein -
  R4712_RS02910 - 581244..581483 (+) 240 WP_001813906.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28754.98 Da        Isoelectric Point: 6.5884

>NTDB_id=895848 R4712_RS02875 WP_001219120.1 576676..577413(-) (comE/blpR) [Streptococcus pneumoniae strain 16H2041]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895848 R4712_RS02875 WP_001219120.1 576676..577413(-) (comE/blpR) [Streptococcus pneumoniae strain 16H2041]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363