Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   R4715_RS05410 Genome accession   NZ_CP137108
Coordinates   1071720..1071845 (+) Length   41 a.a.
NCBI ID   WP_000799689.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain OXT     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1066720..1076845
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4715_RS05385 dnaA 1067205..1068566 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  R4715_RS05390 spo0J 1068779..1069537 (-) 759 WP_317829975.1 ParB/RepB/Spo0J family partition protein Regulator
  R4715_RS05395 htrA 1069595..1070776 (-) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4715_RS05400 rlmH 1070959..1071438 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4715_RS05410 comC/comC1 1071720..1071845 (+) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  R4715_RS05415 comD/comD1 1071866..1073191 (+) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  R4715_RS05420 comE 1073188..1073940 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4715_RS05435 - 1074183..1074725 (-) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  R4715_RS05440 - 1074905..1075979 (+) 1075 Protein_1074 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4971.00 Da        Isoelectric Point: 11.0775

>NTDB_id=895703 R4715_RS05410 WP_000799689.1 1071720..1071845(+) (comC/comC1) [Streptococcus pneumoniae strain OXT]
MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=895703 R4715_RS05410 WP_000799689.1 1071720..1071845(+) (comC/comC1) [Streptococcus pneumoniae strain OXT]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
ATTGTCAAAATTCTTCCGTGATTTTATTTTACAAAGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

100

100

1
  comC/comC1 Streptococcus pneumoniae G54

100

100

1
  comC/comC1 Streptococcus pneumoniae D39

100

100

1
  comC/comC1 Streptococcus pneumoniae Rx1

100

100

1
  comC/comC2 Streptococcus pneumoniae A66

80.488

100

0.805
  comC/comC2 Streptococcus pneumoniae TIGR4

80.488

100

0.805
  comC Streptococcus mitis SK321

78.049

100

0.78
  comC Streptococcus mitis NCTC 12261

74.074

65.854

0.488
  comC/blpC Streptococcus mutans UA159

44.444

87.805

0.39