Detailed information NTG0895599

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: R4702_RS10425
• Genome accession: NZ_CP137106
• Coordinates: 2027767..2028615 (+)
• Length: 282 a.a.
• NCBI ID: WP_317809933.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 16P4028
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 2022767..2033615

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4702_RS10400	-	2023482..2024189 (+)	708	WP_000638502.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
R4702_RS10405	-	2024194..2025216 (+)	1023	WP_000609885.1	ribitol-5-phosphate dehydrogenase	-
R4702_RS10410	licA	2025233..2026102 (+)	870	WP_000411216.1	choline kinase LicA	-
R4702_RS10415	-	2026092..2026970 (+)	879	WP_000837618.1	DMT family transporter	-
R4702_RS10420	-	2026982..2027671 (+)	690	WP_000643970.1	sugar phosphate nucleotidyltransferase	-
R4702_RS10425	dprA/cilB/dalA	2027767..2028615 (+)	849	WP_317809933.1	DNA-processing protein DprA	Machinery gene
R4702_RS10430	-	2029452..2030495 (+)	1044	WP_001812710.1	TIGR00341 family protein	-
R4702_RS10435	topA	2030662..2032749 (+)	2088	WP_000179638.1	type I DNA topoisomerase	-
R4702_RS10440	-	2032970..2033329 (+)	360	WP_001220357.1	YbaN family protein	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31092.71 Da
• Isoelectric Point: 5.2061

>NTDB_id=895599 R4702_RS10425 WP_317809933.1 2027767..2028615(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 16P4028]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLALSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPDSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=895599 R4702_RS10425 WP_317809933.1 2027767..2028615(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 16P4028]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAACAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGCTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACCTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGATAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.291	100	0.993
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.291	100	0.993
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	97.872	100	0.979
dprA/cilB/dalA	Streptococcus mitis SK321	97.163	100	0.972
dprA	Streptococcus mutans UA159	62.857	99.291	0.624
dprA	Lactococcus lactis subsp. cremoris KW2	55	99.291	0.546
dprA	Staphylococcus aureus N315	37.102	100	0.372