Detailed information NTG0895232

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R4709_RS02715
• Genome accession: NZ_CP137102
• Coordinates: 539822..540409 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 16H3071-2
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 534822..545409

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4709_RS02665	-	535216..535449 (-)	234	WP_000379956.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
R4709_RS02670	blpN	535693..535896 (-)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
R4709_RS02675	blpM	535912..536166 (-)	255	Protein_532	two-peptide bacteriocin subunit BlpM	-
R4709_RS02680	-	536317..537122 (-)	806	Protein_533	IS5 family transposase	-
R4709_RS02685	-	537325..537728 (-)	404	Protein_534	immunity protein	-
R4709_RS02690	-	537725..537889 (-)	165	WP_000727118.1	hypothetical protein	-
R4709_RS02695	-	538186..538305 (-)	120	WP_050233614.1	PncF family bacteriocin immunity protein	-
R4709_RS02700	blpU	538308..538538 (-)	231	WP_050243503.1	bacteriocin-like peptide BlpU	-
R4709_RS02705	blpJ	538607..538876 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
R4709_RS02710	blpI	539343..539540 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
R4709_RS02715	comA/nlmT	539822..540409 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R4709_RS02720	blpA	540336..541604 (+)	1269	Protein_541	peptide cleavage/export ABC transporter BlpA	-
R4709_RS02725	comA/nlmT	541814..541978 (+)	165	WP_306420852.1	hypothetical protein	Regulator
R4709_RS02730	-	541989..543350 (+)	1362	WP_050233594.1	bacteriocin secretion accessory protein	-
R4709_RS02735	blpC	543407..543562 (+)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
R4709_RS02740	-	543606..544946 (-)	1341	WP_001099893.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=895232 R4709_RS02715 WP_000205166.1 539822..540409(+) (comA/nlmT) [Streptococcus pneumoniae strain 16H3071-2]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=895232 R4709_RS02715 WP_000205166.1 539822..540409(+) (comA/nlmT) [Streptococcus pneumoniae strain 16H3071-2]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTATTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497