Detailed information NTG0895132

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R4703_RS08610
• Genome accession: NZ_CP137100
• Coordinates: 1592064..1592651 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain LYP
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1587064..1597651

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4703_RS08590	-	1587528..1588868 (+)	1341	WP_001028044.1	sensor histidine kinase	-
R4703_RS08595	blpC	1588910..1589065 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
R4703_RS08600	-	1589122..1590483 (-)	1362	Protein_1651	bacteriocin secretion accessory protein	-
R4703_RS08605	comA/nlmT	1590494..1592170 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator
R4703_RS08610	comA/nlmT	1592064..1592651 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R4703_RS08615	blpI	1592933..1593130 (+)	198	WP_001093261.1	bacteriocin-like peptide BlpI	-
R4703_RS08620	blpJ	1593597..1593866 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
R4703_RS08625	blpU	1593935..1594165 (+)	231	WP_000379967.1	bacteriocin-like peptide BlpU	-
R4703_RS08630	-	1594168..1594287 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
R4703_RS08635	-	1594584..1594748 (+)	165	WP_000727118.1	hypothetical protein	-
R4703_RS08640	-	1594745..1595149 (+)	405	WP_000846944.1	hypothetical protein	-
R4703_RS08645	-	1595352..1596157 (+)	806	Protein_1660	IS5 family transposase	-
R4703_RS08650	blpM	1596307..1596561 (+)	255	WP_000379877.1	two-peptide bacteriocin subunit BlpM	-
R4703_RS08655	blpN	1596577..1596780 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
R4703_RS08660	cipB	1597024..1597173 (+)	150	WP_001820573.1	bacteriocin-like peptide BlpO	Regulator
R4703_RS08665	-	1597277..1597396 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=895132 R4703_RS08610 WP_000205166.1 1592064..1592651(-) (comA/nlmT) [Streptococcus pneumoniae strain LYP]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=895132 R4703_RS08610 WP_000205166.1 1592064..1592651(-) (comA/nlmT) [Streptococcus pneumoniae strain LYP]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497