Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4703_RS00430 Genome accession   NZ_CP137100
Coordinates   86098..86802 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain LYP     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 81098..91802
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4703_RS00400 - 81291..82277 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  R4703_RS00405 - 82533..83309 (-) 777 WP_044791794.1 potassium channel family protein -
  R4703_RS00410 - 83356..83610 (-) 255 WP_023396660.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4703_RS00415 relB 83612..83854 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R4703_RS00420 vicX 83945..84754 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4703_RS00425 micB 84756..86105 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4703_RS00430 micA 86098..86802 (-) 705 WP_000722076.1 response regulator YycF Regulator
  R4703_RS00435 mutY 86857..88032 (-) 1176 WP_050200991.1 A/G-specific adenine glycosylase -
  R4703_RS00440 - 88129..88254 (+) 126 WP_001818232.1 hypothetical protein -
  R4703_RS00445 - 88360..90030 (-) 1671 WP_000845279.1 formate--tetrahydrofolate ligase -
  R4703_RS00450 coaB 90260..90949 (+) 690 WP_000699499.1 phosphopantothenate--cysteine ligase -
  R4703_RS00455 coaC 90961..91512 (+) 552 WP_050200992.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=895064 R4703_RS00430 WP_000722076.1 86098..86802(-) (micA) [Streptococcus pneumoniae strain LYP]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=895064 R4703_RS00430 WP_000722076.1 86098..86802(-) (micA) [Streptococcus pneumoniae strain LYP]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38