Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4714_RS00500 Genome accession   NZ_CP137099
Coordinates   96750..97454 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 20824-4     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 91750..102454
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4714_RS00470 - 91931..92917 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  R4714_RS00475 - 93218..93961 (-) 744 Protein_94 potassium channel family protein -
  R4714_RS00480 - 94008..94262 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4714_RS00485 relB 94264..94506 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R4714_RS00490 vicX 94597..95406 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4714_RS00495 micB 95408..96757 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4714_RS00500 micA 96750..97454 (-) 705 WP_000722076.1 response regulator YycF Regulator
  R4714_RS00505 mutY 97509..98684 (-) 1176 WP_000886153.1 A/G-specific adenine glycosylase -
  R4714_RS00510 - 99012..100682 (-) 1671 WP_000845284.1 formate--tetrahydrofolate ligase -
  R4714_RS00515 coaB 100912..101601 (+) 690 WP_000699495.1 phosphopantothenate--cysteine ligase -
  R4714_RS00520 coaC 101613..102164 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=894987 R4714_RS00500 WP_000722076.1 96750..97454(-) (micA) [Streptococcus pneumoniae strain 20824-4]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=894987 R4714_RS00500 WP_000722076.1 96750..97454(-) (micA) [Streptococcus pneumoniae strain 20824-4]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38